Subclinical encephalopathy
Subclinical encephalopathy
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DOI：
10.1159/000171577
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发表时间：
1996-01-01
影响因子：
2.3
通讯作者：
Cordoba, J
中科院分区：
文献类型：
--
作者：
Blei, AT;Cordoba, J
亚临床肝性脑病(SHE) -在没有明显脑病的情况下的认知缺陷-经常出现在肝硬化患者中。在缺乏生物学相关性的情况下，SHE的诊断依赖于心理测量测试。注意力和运动异常是最常见的神经认知缺陷。睡眠障碍——肝硬化的常见症状——可能是SHE的一部分。SHE对日常活动的影响是有争议的，因为患者可能会适应他们的生活认知限制。要求高的活动，如驾驶机动车辆，可能会受到损害，尽管全面限制似乎为时过早。治疗SHE的益处尚未确定。抗脑病药物可能是有效的，可以考虑在某些个体。
Subclinical hepatic encephalopathy (SHE) - cognitive deficits in the absence of overt encephalopathy - is frequently present in patients with cirrhosis. In the absence of biological correlates, diagnosis of SHE relies on psychometric tests. Attentional and motor abnormalities are the most common neurocognitive deficits. Sleep disturbances - a frequent complaint in cirrhosis - may be part of the spectrum of SHE. The impact of SHE on daily activities is controversial as patients may adapt their lives to cognitive limitations. Demanding activities, such as driving motor vehicles, may be impaired, though a blanket restriction appears premature. The benefit of treating SHE is not established. Antiencephalopathic drugs may be effective and can be considered in certain individuals.