Repeated fluvoxamine treatment recovers early postnatal stress-induced hypersociability-like behavior in adult rats.
Repeated fluvoxamine treatment recovers early postnatal stress-induced hypersociability-like behavior in adult rats.
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DOI：
10.1016/j.jphs.2017.12.002
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发表时间：
2017-12
影响因子：
3.5
通讯作者：
H. Kumamoto;Taku Yamaguchi;Kohtarou Konno;T. Izumi;Takayuki Yoshida;Yu Ohmura;Masahiko Watanabe;M. Yoshioka
中科院分区：
文献类型：
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作者：
H. Kumamoto;Taku Yamaguchi;Kohtarou Konno;T. Izumi;Takayuki Yoshida;Yu Ohmura;Masahiko Watanabe;M. Yoshioka
儿童期虐待与成年期大脑功能受损有关，特别是海马体，不仅是某些精神疾病的主要风险因素，而且还影响早期社会发展和晚年社会适应。本研究的目的是确定产后早期压力是否会影响社会行为，以及重复氟伏沙明治疗是否会逆转这些变化。在出生后第21-25天（3周龄：3 wFS），将大鼠幼仔暴露于足电击应激。在后青春期（生后10-14周），进行社会互动试验和背海马锥体神经元Golgi-cox染色。暴露于footshock应激后，3 wFS大鼠表现出社会互动时间的增加，这可能是几乎同义的hypersociability，和减少在CA 3海马区的脊椎密度，但不是在CA 1。通过以10 mg/kg/天的剂量重复经口给予氟伏沙明14天，这些行为和形态学变化均得到恢复。这些研究结果表明，海马CA 3区的脆弱性是密切相关的社会障碍引起的身体压力在青少年时期，并揭示了一些治疗方案的早期产后压力引起的情绪障碍。
Childhood maltreatment is associated with impaired adult brain function, particularly in the hippocampus, and is not only a major risk factor for some psychiatric diseases but also affects early social development and social adaptation in later life. The aims of this study were to determine whether early postnatal stress affects social behavior and whether repeated fluvoxamine treatment reverses these changes. Rat pups were exposed to footshock stress during postnatal days 21–25 (at 3 weeks old: 3wFS). During the post-adolescent period (10–14 weeks postnatal), the social interaction test and Golgi-cox staining of dorsal hippocampal pyramidal neurons were performed. Following exposure to footshock stress, 3wFS rats showed an increase in social interaction time, which might be practically synonymous with hypersociability, and a decrease in spine density in the CA3 hippocampal subregion, but not in CA1. These behavioral and morphological changes were both recovered by repeated oral administration of fluvoxamine at a dose of 10 mg/kg/day for 14 days. These findings suggest that the vulnerability of the hippocampal CA3 region is closely related to social impairments induced by physical stress during the juvenile period and shed some light on therapeutic alternatives for early postnatal stress-induced emotional dysfunction.