A pilot study examining the relationship between stress and serum cortisol concentrations in women with asthma
A pilot study examining the relationship between stress and serum cortisol concentrations in women with asthma
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DOI：
10.1053/rmed.2002.1366
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发表时间：
2002-10-01
影响因子：
4.3
通讯作者：
Fitzgerald, ST
中科院分区：
文献类型：
--
作者：
Laube, BL;Curbow, BA;Fitzgerald, ST
压力加剧哮喘的机制尚不清楚。一种解释可能是压力导致内源性血清皮质醇浓度降低。我们的目的是确定早晨血清皮质醇浓度的降低是否与女性哮喘患者更高水平的压力有关。在这项试点研究中，7名有过敏性哮喘病史的女性被前瞻性地分配到低，中，高压力组的基础上，他们目前的压力水平和他们的资源，以科普压力的组合。在压力组分配后，妇女们捐献了一份早晨的血液样本，由一个独立的实验室分析血清皮质醇浓度，该实验室的工作人员对受试者的压力状态不知情。三名女性被分配到低压力组，两名中度压力组和两名高压力组。血清皮质醇浓度范围为8 - 23 mug/dl，平均14 +/- 6 mug/dl。斯皮尔曼等级相关表明血清皮质醇浓度与应激分组显著负相关（r5（s）= -0.915; P = 0.025）。这些结果表明，早晨血清皮质醇浓度的降低可能与过敏性哮喘女性的压力水平较高和科普压力的资源较少有关。(C)2002爱思唯尔科技有限公司。保留所有权利。
The mechanism (s) by which stress exacerbates asthma is unknown. One explanation could be a reduction in endogenous serum cortisol concentrations as a result of stress. Our objective was to determine if a reduction in morning serum cortisol concentrations is associated with higher levels of stress in women with asthma. In this pilot study, seven women with a history of allergic-asthma were prospectively assigned to either low, moderate, or high stress groups based on a combination of their level of current stress and their resources to cope with the stress. After stress group assignment, women donated a morning blood sample, which was analyzed for serum cortisol concentration by an independent laboratory whose personnel were blinded to the subjects' stress status. Three women were assigned to the low stress group, two to the moderate stress group and two to the high stress group. Serum cortisol concentrations ranged from 8 to 23 mug/dl, averaging 14 +/- 6 mug/dl. A Spearman rank correlation indicated that serum cortisol concentrations were significantly inversely related to the stress groupings (r5(s) = -0.915; P = 0.025). These results suggest that a reduction in morning serum cortisol concentration may be associated with higher levels of stress and lower resources to cope with the stress in women with allergic-asthma. (C) 2002 Elsevier Science Ltd. All rights reserved.