Streptozotocin-induced elevation of pancreatic taurine content and suppressive effect of taurine on insulin secretion.
Streptozotocin-induced elevation of pancreatic taurine content and suppressive effect of taurine on insulin secretion.
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DOI：
10.1016/0014-2999(83)90333-3
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发表时间：
1983-02
影响因子：
5
通讯作者：
H. Tokunaga;Y. Yoneda;K. Kuriyama
中科院分区：
文献类型：
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作者：
H. Tokunaga;Y. Yoneda;K. Kuriyama
研究了牛磺酸在胰腺胰岛素分泌中的作用。胰毒性链脲佐菌素（STZ）诱导小鼠ddY和CD-1株胰腺牛磺酸含量显著增加，并引起该器官β-细胞明显损伤引起的显著高血糖。在STZ诱导的短暂性和持续性高血糖状态下，胰腺牛磺酸含量的增加都是不可避免的。通过分析冻干胰腺切片也表明，STZ诱导的胰腺中牛磺酸含量的升高是由于外分泌组织中牛磺酸水平的升高，而朗格汉斯胰岛中的牛磺酸水平不受STZ的影响。另一方面，体外添加牛磺酸（1-10 mM）可显著抑制朗格汉斯离体胰岛的葡萄糖刺激和Ca2+依赖性胰岛素（IRI）分泌，而不影响该激素的Ca2+依赖性分泌。考虑到上述结果，牛磺酸的作用部位似乎可能在胰岛细胞的外部，也许在朗格汉斯岛的细胞膜上。本研究结果提示，胰牛磺酸可能在调节朗格汉斯胰岛胰岛素分泌和血清葡萄糖水平中发挥重要的生理作用。
The role of taurine in pancreatic insulin secretion was studied. The administration of the pancreato-toxic streptozotocin (STZ) induced a significant increase of pancreatic taurine content in ddY and CD-1 strains of mice in addition to a remarkable hyperglycemia which resulted from significant damage to the β-cells of this organ. The increase in pancreatic taurine content was invariably observed under both the transient and the continuous hyperglycemic conditions induced by STZ. It was also shown by analysing lyophilized pancreatic sections that this elevation of taurine content in the pancreas induced by STZ was due to the rise of taurine level in the exocrine tissues, whereas that in the islets of Langerhans was not affected STZ. On the other hand, the in vitro addition of taurine (1–10 mM) significantly suppressed the glucose-stimulated and Ca2+-dependent secretion of insulin (IRI) from the isolated islets of Langerhans without affecting the Ca2+-independent secretion of this hormone. Considering the results described above, it seems possible that the action site of taurine may be at the exterior of islet cells, perhaps at the cellular membranes of the islets of Langerhans. The present results suggest that pancreatic taurine may play a significant physiological role in the regulation of insulin secretion from the islets of Langerhans and of the serum level of glucose.