The functional neuroanatomy of schizophrenic subsyndromes
The functional neuroanatomy of schizophrenic subsyndromes
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DOI：
10.1017/s0033291703007864
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发表时间：
2003-08-01
影响因子：
6.9
通讯作者：
Bullmore, ET
中科院分区：
文献类型：
--
作者：
Honey, GD;Sharma, T;Bullmore, ET
背景精神分裂症综合征所包含的各种症状的表达在患者之间存在相当大的差异，这可能调节认知过程的功能激活。在这里，我们调查精神分裂症亚综合征评分，确定因素分析，和实验控制的大脑激活之间的关联。对100例精神分裂症患者的PANSS评定量表进行旋转主成分分析，确定5个因子。采用功能磁共振成像（fMRI）技术，对30名患者和27名对照组进行了两个周期性的认知激活实验：言语工作记忆和心理序列实验。因子分析复制了五个维度一致报告。在患者组内，工作记忆激活的功率与左舌和颞顶叶皮质的整体症状严重程度呈负相关;与左下额叶和上级颞叶皮质和基底神经节的阳性子综合征评分呈负相关;与外侧和内侧运动前皮质的阴性子综合征评分呈正相关。在运动任务中，未观察到亚综合征评分与功能激活之间的关系。组间比较显示，患者双侧背外侧前额叶和左侧中央前、后皮质对工作记忆任务的反应能力降低。在这项研究中，我们观察了与精神分裂症症状表达相关的功能反应的任务特异性调制。我们的研究结果与以前的实证研究结果和理论概念化的人脑功能，在激活的能力限制，在面对竞争的需求，从病理和任务相关的认知活动。
Background. There is considerable variability between patients in their expression of the diverse range of symptoms encompassed by the syndrome of schizophrenia, which may modulate functional activation to cognitive processing.Method. Here we investigate associations between schizophrenic subsyndrome scores, identified by factor analysis, and experimentally controlled brain activation. Five factors were defined by rotated principal components analysis of PANSS rating scale measurements in 100 patients with schizophrenia. A subsample of 30 patients and a group of 27 comparison subjects were studied using functional magnetic resonance imaging (fMRI) during the performance of two periodically designed cognitive activation experiments: verbal working memory and psychomotor sequencing.Results. Factor analysis replicated the five dimensions consistently reported. Within the patient a group, power of activation by working memory was negatively associated with global symptom severity in left lingual and temporo-parietal cortices; negatively associated with positive subsyndrome scores in left inferior frontal and superior temporal cortices and basal ganglia; and positively associated with negative subsyndrome scores in lateral and medial premotor cortex. No relationship was observed between subsyndrome scores and functional activation during the motor task. Between-group comparisons demonstrated reduced power of response to the working memory task by patients in bilateral dorsolateral prefrontal and left pre- and post-central cortices.Conclusions. In this study we observed task-specific modulation of functional response associated with symptom expression in schizophrenia. Our findings are compatible with previous empirical findings and theoretical conceptualization of human brain function, in terms of capacity constraints on activation in the face of competing demands from pathological and task-related cognitive activity.