Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling
Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling
复制标题
DOI：
10.1161/01.hyp.0000048340.53100.43
复制
发表时间：
2003-03-01
期刊：
影响因子：
8.3
通讯作者：
Kambe, M
中科院分区：
文献类型：
--
作者：
Oishi, Y;Ozono, R;Kambe, M
本研究旨在探讨AT2受体(AT2R)在心肌梗死(MI)后左室重构中的作用。结扎AT2R基因敲除(Agtr2-)和野生型(Agtr2+)小鼠左前降支。用超声心动图和组织学方法评价心肌梗死后2周的左心室重构。Agtr2+和Agtr2-小鼠第1天的心肌梗死面积相似。Agtr2-小鼠心肌梗死后第14天死亡率为62.9%，与对照组比较差异有统计学意义(P
The aim of this study was to determine the role of the AT2 receptor (AT2R) in left ventricular (LV) remodeling after myocardial infarction (MI). The left anterior descending arteries were ligated in AT2R gene knockout (Agtr2-) and wild-type (Agtr2+) mice. The LV remodeling was evaluated by echocardiography and histology over a period of 2 weeks after MI. The infarct sizes in hearts excised from Agtr2+ and Agtr2- mice on day 1 were similar. The mortality rate of Agtr2- mice (62.9%) on day 14 after MI was significantly (P