GAP JUNCTIONAL COMMUNICATION AND THE DEVELOPMENT OF LOCAL CIRCUITS IN NEOCORTEX
GAP JUNCTIONAL COMMUNICATION AND THE DEVELOPMENT OF LOCAL CIRCUITS IN NEOCORTEX
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DOI：
10.1093/cercor/3.5.488
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发表时间：
1993-09-01
期刊：
影响因子：
3.7
通讯作者：
KATZ, LC
中科院分区：
文献类型：
--
作者：
PEINADO, A;YUSTE, R;KATZ, LC
在大脑新皮层，以及大脑的许多其他区域，对类似刺激特征做出反应的神经元通常是彼此靠近的。在这里，我们研究了间隙连接通信在形成和定义这些局部神经元群中的可能作用，其中的例子可能是在几乎所有哺乳动物物种的新皮层中发现的列。我们已经在脑皮层切片实验中探讨了这个问题，使用钙成像来可视化多细胞活动模式，并使用示踪剂注射来识别发育中的新皮层中间隙连接耦合的解剖模式。我们的研究结果表明，树突间隙连接通信可能参与局部连接的形成，最有可能是通过同步相邻神经元之间的电或生化活动。
In the neocortex, as well as in many other brain regions, neurons responding to similar stimulus features are usually found close to one another. Here we examine the possible role of gap junctional communication in forming and defining these local neuronal groupings, examples of which may be the columns found in the neocortex of virtually all mammalian species. We have approached this question experimentally in cortical brain slices using calcium imaging to visualize multicellular activity patterns, and tracer injections to identify the anatomical pattern of gap junction coupling in the developing neocortex. Our results suggest that dendrodendritic gap junctional communication may be involved in the formation of local connectivity, most likely by synchronizing electrical or biochemical activity among neighboring neurons.