Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review.
Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review.
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DOI：
10.1016/j.phrs.2021.105841
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发表时间：
2021-08
影响因子：
9.3
通讯作者：
O. Yazarlu;M. Iranshahi;Hamid Reza Khayat Kashani;Sara Reshadat;S. Habtemariam;Milad Iranshahy;Maede Hasanpour
中科院分区：
文献类型：
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作者：
O. Yazarlu;M. Iranshahi;Hamid Reza Khayat Kashani;Sara Reshadat;S. Habtemariam;Milad Iranshahy;Maede Hasanpour
伤口是指对身体的任何伤害，例如皮肤表皮的损伤及其正常解剖结构和功能的干扰。自古以来，人们就认识到伤口愈合的重要性，并做出了许多努力来开发由最好的材料制成的新型伤口敷料，以实现快速有效的伤口愈合。药用植物在伤口愈合过程中发挥着重要作用。近几十年来，许多研究都集中在开发新的伤口敷料，包括药用植物提取物或其纯化的活性化合物，这是传统伤口敷料的潜在替代品。一些研究还调查了各种草药在伤口愈合过程中的作用机制。本文试图强调和审查的机制的角度伤口愈合介导的植物为基础的天然产物。研究结果表明，草药通过多种机制发挥作用，并参与伤口愈合的各个阶段。某些中药可增加血管内皮生长因子（VEGF）和转化生长因子-β（TGF-β）的表达，它们在刺激上皮再生、血管生成、肉芽组织形成和胶原纤维沉积中起重要作用。其他一些含有草药的伤口敷料可作为肿瘤坏死因子-α（TNF-α）、白细胞介素-1 β（IL-1 β）和诱导型一氧化氮合酶（iNOS）蛋白表达的抑制剂，从而在伤口愈合过程的各个阶段诱导抗氧化和抗炎特性。除了公众对传统和替代医学的兴趣日益增长外，使用草药和天然产品进行伤口愈合与传统药物相比具有许多优势，包括由于不同的作用机制，抗菌活性和长期伤口敷料使用的安全性而具有更高的有效性。
Wound is defined as any injury to the body such as damage to the epidermis of the skin and disturbance to its normal anatomy and function. Since ancient times, the importance of wound healing has been recognized, and many efforts have been made to develop novel wound dressings made of the best material for rapid and effective wound healing. Medicinal plants play a great role in the wound healing process. In recent decades, many studies have focused on the development of novel wound dressings that incorporate medicinal plant extracts or their purified active compounds, which are potential alternatives to conventional wound dressings. Several studies have also investigated the mechanism of action of various herbal medicines in wound healing process. This paper attempts to highlight and review the mechanistic perspective of wound healing mediated by plant-based natural products. The findings showed that herbal medicines act through multiple mechanisms and are involved in various stages of wound healing. Some herbal medicines increase the expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) which play important role in stimulation of re-epithelialization, angiogenesis, formation of granulation tissue, and collagen fiber deposition. Some other wound dressing containing herbal medicines act as inhibitor of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and inducible nitric oxide synthase (iNOS) protein expression thereby inducing antioxidant and anti-inflammatory properties in various phases of the wound healing process. Besides the growing public interest in traditional and alternative medicine, the use of herbal medicine and natural products for wound healing has many advantages over conventional medicines, including greater effectiveness due to diverse mechanisms of action, antibacterial activity, and safety in long-term wound dressing usage.