PPARα gene variation and physical performance in Russian athletes
PPARα gene variation and physical performance in Russian athletes
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DOI：
10.1007/s00421-006-0154-4
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发表时间：
2006-05-01
影响因子：
3
通讯作者：
Rogozkin, VA
中科院分区：
文献类型：
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作者：
Ahmetov, II;Mozhayskaya, IA;Rogozkin, VA
过氧化物酶体增殖物激活受体α(PPARα)调节与骨骼和心肌脂肪酸氧化有关的基因。以往的研究表明，PPARα内含子7 G/C多态性与运动后左心室的生长有关。我们推测，GG纯合子在一组以耐力为导向的运动员中更普遍，具有正常的脂肪酸代谢，并增加了慢抽动纤维的百分比。我们在对13个不同运动项目的786名俄罗斯运动员的混合队列研究中验证了这一假设，这些运动员按成绩前瞻性地分层(耐力型运动员、力量型运动员和混合耐力/力量型活动的运动员)。将PPARα内含子7的基因型和等位基因频率与1242名对照组进行比较。我们发现C等位基因随着体能中无氧成分的增加呈线性增加趋势(P=0.029)。耐力型和力量型运动员GG基因频率分别为80.3%和50.6%，与对照组(70.0%)相比差异有统计学意义(P<；0.0001)。为了研究PPARα基因变异与纤维类型组成之间的关系，对40名年轻男性的股外侧肌进行了肌肉活检。GG纯合子(n=25)慢收缩纤维百分率(55.5+/-2.0vs38.5+/-2.3%)显著高于CC纯合子(n=4)(P=0.003)。综上所述，PPARα基因内含子7 G/C多态性与俄罗斯运动员的体能表现有关，这可能部分是由于PPARα基因与肌纤维类型组成之间的关联。
Peroxisome proliferator-activated receptor alpha (PPAR alpha) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPAR alpha intron 7 G/C polymorphism was associated with left ventricular growth in response to exercise. We speculated that GG homozygotes should be more prevalent within a group of endurance-oriented athletes, have normal fatty acid metabolism, and increased percentages of slow-twitch fibers. We have tested this hypothesis in the study of a mixed cohort of 786 Russian athletes in 13 different sporting disciplines prospectively stratified by performance (endurance-oriented athletes, power-oriented athletes and athletes with mixed endurance/power activity). PPAR alpha intron 7 genotype and allele frequencies were compared to 1,242 controls. We found an increasing linear trend of C allele with increasing anaerobic component of physical performance (P=0.029). GG genotype frequencies in endurance-oriented and power-oriented athletes were 80.3 and 50.6%, respectively, and were significantly (P < 0.0001) different compared to controls (70.0%). To examine the association between PPAR alpha gene variant and fiber type composition, muscle biopsies from m. vastus lateralis were obtained and analyzed in 40 young men. GG homozygotes (n=25) had significantly (P=0.003) higher percentages of slow-twitch fibers (55.5 +/- 2.0 vs 38.5 +/- 2.3%) than CC homozygotes (n=4). In conclusion, PPAR alpha intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPAR alpha genotype and muscle fiber type composition.