Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position.
Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position.
复制标题
脂肪质量和肥胖基因（FTO）基因影响非耐药训练的男性和精英橄榄球比赛地位的骨骼肌表型。
DOI：
10.1186/s12863-017-0470-1
复制
发表时间：
2017-01-19
期刊：
影响因子：
2.9
通讯作者：
Williams AG
中科院分区：
文献类型：
--
作者：
Heffernan SM;Stebbings GK;Kilduff LP;Erskine RM;Day SH;Morse CI;McPhee JS;Cook CJ;Vance B;Ribbans WJ;Raleigh SM;Roberts C;Bennett MA;Wang G;Collins M;Pitsiladis YP;Williams AG
FTO基因变异与久坐不动和肥胖人群的肥胖表型有关，但很少与骨骼肌和优秀运动员的表型有关。在1089名参与者中，包括530名精英橄榄球运动员和559名非运动员，收集了DNA，并使用实时荧光聚合酶链式反应对FTO rs9939609变异进行了基因分型。在一组未接受阻力训练的个体(NT；n = 120)中，我们还使用双能X射线吸收法、超声波和等速测力法评估了骨骼肌的结构和功能表型。在橄榄球运动员的一个小组(n = 77)中，我们评估了反动作跳跃中的肌肉力量。在NT中，TT等位基因携带者和T等位基因携带者的全身(4.8%和4.1%)和总阑尾瘦质量(Lm；3.0%和2.1%)高于AA型，T等位基因携带者的手臂Lm(0.8%)和TT腿Lm(2.1%)比AA型大(2.1%)。此外，与其他橄榄球运动员(82%；P = 0.0 1，OR = 3.34)和对照组(84%；P = 0.0 3，或 = 2.88)相比，T等位基因在那些最依赖LM而不是总体重获得成功的优秀橄榄球联盟运动员中更为常见(94%)。因此，这些运动员相对于体重的峰值功率比其他橄榄球运动员更大(14%；P = 为2×10-6)。总而言之，这些结果表明，T等位基因与LM增加和精英运动成功相关。这对运动人群以及以低Lm为特征的情况，如石棺减少和恶病质，都有影响。
FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes. In 1089 participants, comprising 530 elite rugby athletes and 559 non-athletes, DNA was collected and genotyped for the FTO rs9939609 variant using real-time PCR. In a subgroup of non-resistance trained individuals (NT; n = 120), we also assessed structural and functional skeletal muscle phenotypes using dual energy x-ray absorptiometry, ultrasound and isokinetic dynamometry. In a subgroup of rugby athletes (n = 77), we assessed muscle power during a countermovement jump. In NT, TT genotype and T allele carriers had greater total body (4.8% and 4.1%) and total appendicular lean mass (LM; 3.0% and 2.1%) compared to AA genotype, with greater arm LM (0.8%) in T allele carriers and leg LM (2.1%) for TT, compared to AA genotype. Furthermore, the T allele was more common (94%) in selected elite rugby union athletes (back three and centre players) who are most reliant on LM rather than total body mass for success, compared to other rugby athletes (82%; P = 0.01, OR = 3.34) and controls (84%; P = 0.03, OR = 2.88). Accordingly, these athletes had greater peak power relative to body mass than other rugby athletes (14%; P = 2 x 10-6). Collectively, these results suggest that the T allele is associated with increased LM and elite athletic success. This has implications for athletic populations, as well as conditions characterised by low LM such as sarcopenia and cachexia.