High dietary inorganic phosphate enhances cap-dependent protein translation, cell-cycle progression, and angiogenesis in the livers of young mice.
High dietary inorganic phosphate enhances cap-dependent protein translation, cell-cycle progression, and angiogenesis in the livers of young mice.
复制标题
高膳食无机磷酸盐可增强幼鼠肝脏中帽子依赖性蛋白质翻译、细胞周期进程和血管生成。
DOI：
10.1152/ajpgi.90213.2008
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Cho,Myung-Haing
中科院分区：
文献类型：
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作者：
Xu,Cheng-Xiong;Jin,Hua;Lim,Hwang-Tae;Kim,Ji-Eun;Shin,Ji-Young;Lee,Eun-Sun;Chung,Youn-Sun;Lee,Yeon-Sook;BeckJr,George;Lee,KeeHo;Cho,Myung-Haing
Inorganic phosphate (Pi) plays a key role in diverse physiological functions. Recent studies have indicated that Piaffects Akt signaling through the sodium-dependent phosphate cotransporter. Akt signaling, in turn, plays an important role in liver development; however, the effects of high dietary Pion the liver have not been investigated. Here, we examined the effects of high dietary phosphate on the liver in developing mice. We found that high dietary Piincreased liver mass through enhancing Akt-related cap-dependent protein translation, cell cycle progression, and angiogenesis. Thus careful regulation of Piconsumption may be important in maintaining normal development of the liver.
