Genomic organization of the family of CNR cadherin genes in mice and humans
Genomic organization of the family of CNR cadherin genes in mice and humans
复制标题
DOI：
10.1006/geno.1999.6066
复制
发表时间：
2000-01-01
期刊：
影响因子：
4.4
通讯作者：
Yagi, T
中科院分区：
文献类型：
--
作者：
Sugino, H;Hamada, S;Yagi, T
钙粘素相关神经元受体(CNR)家族定位于突触连接，其胞浆结构域与Fyn酪氨酸激酶相互作用，本文描述了CNR家族成员在小鼠和人类中的染色体位置和同源基因组结构。在基因组组织中，不同的外显子(每个外显子编码不同的CNR的N端)聚集在串联阵列中，这些外显子被拼接到由三个外显子组成的公共区域(恒定区)。我们还发现了转录本的三种不同版本；单个可变外显子与三个不同的C末端尾巴相连，类似于免疫球蛋白重链中的类别切换。因此，中枢神经系统中的CNR家族与免疫系统中的免疫球蛋白和T细胞受体基因有相似之处。(C)2000年学术出版社。
The cadherin-related neuronal receptor (CNR) family is localized to the synaptic junction, and their cytoplasmic domains interact with Fyn-tyrosine kinase, Here, we describe the chromosomal locations and the orthologous genomic structures of CNR family members in mice and humans, In the genomic organization, distinct exons, each of which encodes the N-terminus of a different CNR ("variable region"), are clustered in a tandem array, and these exons are spliced to a common region composed of three exons ("constant region"). We also discovered three alternative versions of the transcripts; a single variable exon connects with three different C-terminal tails, comparable to class-switching in the immunoglobulin heavy chain. Thus the CNR family in the central nervous system has similarities to the immunoglobulin and T-cell receptor genes in the immune system. (C) 2000 Academic Press.