Elevated Sera sST2 Is Associated With Heart Failure in Men ≤50 Years Old With Myocarditis
Elevated Sera sST2 Is Associated With Heart Failure in Men ≤50 Years Old With Myocarditis
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DOI：
10.1161/jaha.118.008968
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发表时间：
2019-01-22
影响因子：
5.4
通讯作者：
Fairweather, DeLisa
中科院分区：
文献类型：
--
作者：
Coronado, Michael J.;Bruno, Katelyn A.;Fairweather, DeLisa
背景心肌炎是急、慢性心力衰竭的重要原因。与女性相比，患有心肌炎的男性恢复情况较差，移植需求增加，但性别差异的原因尚不清楚。血清可溶性ST 2升高可预测急性和慢性心力衰竭的死亡率，但尚未在心肌炎patients.Methods和Results中进行研究，根据2013年欧洲心脏病学会的立场声明，诊断为临床疑似心肌炎的成人（n=303，78%为男性）。通过ELISA检测人和小鼠的血清sST 2水平，并根据性别和年龄与心脏功能相关。与女性相比，健康男性（P=8 x 10（-6））和心肌炎男性（P=0.004）的血清sST 2水平更高。心肌炎和纽约心脏协会III-IV级心力衰竭患者sST 2水平升高（P=0.002），主要发生在男性（P=0.0003）。血清sST 2水平与心肌炎患者的纽约心脏协会分级相关，
Background Myocarditis is an important cause of acute and chronic heart failure. Men with myocarditis have worse recovery and an increased need for transplantation compared with women, but the reason for the sex difference remains unclear. Elevated sera soluble (s)ST2 predicts mortality from acute and chronic heart failure, but has not been studied in myocarditis patients.Methods and Results Adults with a diagnosis of clinically suspected myocarditis (n=303, 78% male) were identified according to the 2013 European Society of Cardiology position statement. Sera sST2 levels were examined by ELISA in humans and mice and correlated with heart function according to sex and age. Sera sST2 levels were higher in healthy men (P=8 x 10(-6)) and men with myocarditis (P=0.004) compared with women. sST2 levels were elevated in patients with myocarditis and New York Heart Association class III-IV heart failure (P=0.002), predominantly in men (P=0.0003). Sera sST2 levels were associated with New York Heart Association class in men with myocarditis who were