CONTINUOUS LYMPHOID-CELL LINES WITH CHARACTERISTICS OF B-CELLS (BONE-MARROW-DERIVED), LACKING EPSTEIN-BARR VIRUS GENOME AND DERIVED FROM 3 HUMAN LYMPHOMAS
CONTINUOUS LYMPHOID-CELL LINES WITH CHARACTERISTICS OF B-CELLS (BONE-MARROW-DERIVED), LACKING EPSTEIN-BARR VIRUS GENOME AND DERIVED FROM 3 HUMAN LYMPHOMAS
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DOI：
10.1073/pnas.71.8.3283
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发表时间：
1974-01-01
影响因子：
11.1
通讯作者：
SUNDSTROM, C
中科院分区：
文献类型：
--
作者：
KLEIN, G;LINDAHL, T;SUNDSTROM, C
通过核酸杂交（互补RNA·DNA）和EB病毒确定的核抗原试验，对三种特殊细胞系进行了EB病毒基因组检测。两个品系来自瑞典淋巴瘤病例，一个来自非洲伯基特样淋巴瘤活检，该活检对EB病毒DNA和病毒确定的核抗原呈阴性。所有三个系显然都缺乏病毒基因组。三个细胞系中有两个明显具有B细胞（骨髓来源）的特征。
Three exceptional cell lines have been tested for the presence of the Epstein-Barr virus genome by nucleic acid hybridization (complementary RNA·DNA) and Epstein-Barr virus-determined nuclear antigen tests. Two lines were derived from Swedish lymphoma cases and one from an African Burkitt-like lymphoma biopsy that was negative for Epstein-Barr virus DNA and the virus-determined nuclear antigen. All three lines apparently lacked the viral genome. Two of the three lines clearly had characteristics of B-cells (bone-marrow-derived).