Non-coding RNAs derailed: The many influences on the fatty acid reprogramming of cancer.
Non-coding RNAs derailed: The many influences on the fatty acid reprogramming of cancer.
复制标题
DOI：
10.1016/j.lfs.2019.05.065
复制
发表时间：
2019-08
期刊：
影响因子：
6.1
通讯作者：
Xiang-hua Yu;Hao-Fan Wang;Jing-biao Wu;Sha-Sha Wang-Sha;Ya-Jie Tang;Ya-Ling Tang;Xin-hua Liang
中科院分区：
文献类型：
--
作者：
Xiang-hua Yu;Hao-Fan Wang;Jing-biao Wu;Sha-Sha Wang-Sha;Ya-Jie Tang;Ya-Ling Tang;Xin-hua Liang
非编码RNA （NcRNAs）是一类不能转化为蛋白质但控制特定基因表达程序的功能性RNA分子，已被证明与多种生物过程有关，包括脂肪酸代谢。快速生长的肿瘤细胞通过调节脂肪酸代谢过程中的多种关键酶及相关信号通路，对其脂肪酸代谢回路进行重新布线，以满足能量储存、膜增殖和信号分子生成的需要。这篇综述介绍了我们对ncrna -特别是microRNAs （miRNAs）、长链非编码rna （lncRNAs）和环状rna （circRNAs）在这种代谢转变中的调控网络的最新认识，并讨论了基于ncrna的治疗方法应用于恢复癌症相关脂肪酸代谢的可能性。
Non-coding RNAs (NcRNAs), a family of functional RNA molecules that cannot translate into proteins but control specific gene expression programs, have been shown to be implicated in various biological processes, including fatty acid metabolism. Fast-growing tumor cells rewire their fatty acid metabolic circuitry in order to meet the needs of energy storage, membrane proliferation, and the generation of signaling molecules, which is achieved by regulating a variety of key enzymes along with related signaling pathways in fatty acid metabolism. This review presents an update of our knowledge about the regulatory network of ncRNAs—specifically, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs)—in this metabolic shift and discusses the possibility of ncRNA-based therapeutics being applied to the restoration of cancer-related fatty acid metabolism.