Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa:: Genome size, antioxidant potential and phytochemistry
Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa:: Genome size, antioxidant potential and phytochemistry
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DOI：
10.1055/s-2008-1034358
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发表时间：
2008-03-01
期刊：
影响因子：
2.7
通讯作者：
Murch, Susan J.
中科院分区：
文献类型：
--
作者：
Cole, Ian B.;Cao, Jin;Murch, Susan J.
唇形科中的紫珠属有超过350种，其中许多是药用活性的。其中一个物种，黄芩，是中国传统医学中最广泛的处方植物之一，用于神经系统疾病，癌症和炎症疾病，并一直是详细的科学研究的主题，但对其他黄芩的植物化学知之甚少。本研究的目的是比较3种紫藤属植物用于治疗神经系统疾病的药用植物化学。为了实现这一目标，具体的目标是（a）建立一个体外收集的南美本土; S。（B）对S.总状花序的植物化学特征;总状花序S. baicalensis和S.侧花S.从佛罗里达的野生种群中体外建立总状花序。植物学上，S。总状花序为二倍体，染色体数为18，流式细胞仪分析表明，总状花序为二倍体，染色体数为18。baicalensis和S.总状花序具有小的细胞核，估计基因组较小（分别为377 mbp和411 mbp）。抗氧化能力的研究表明，3种紫藤属植物的抗氧化能力没有显著差异。植物化学分析检测和定量的黄酮黄芩苷，黄芩素，野黄芩苷，汉黄芩素以及人类神经激素褪黑激素和血清素在叶和茎组织。baicalensis、S. lateriflora和S.总状花序。这些发现代表了第一个植物化学分析S。总状花序，建立S.总状花序是药用植物次生代谢研究的模式系统，也是治疗人类疾病的重要植物药物的潜在来源。
The genus Scutellaria in the family Lamiaceae has over 350 species, many of which are medicinally active. One species, Scutellaria baicalensis, is one of the most widely prescribed plants in Traditional Chinese Medicine, used for neurological disorders, cancer and inflammatory diseases and has been the subject of detailed scientific study but little is known about the phytochemistry of other Scutellaria. The current study was designed to compare the medicinal phytochemistry of 3 species of Scutellaria used to treat neurological disorders. To accomplish this objective, the specific objectives were (a) to establish an in vitro collection of the South American native; S. racemosa, (b) to botanically characterize S. racemosa and (c) to compare the phytochemistry of S. racemosa with S. baicalensis and S. lateriflora. S. racemosa was established in vitro from wild populations in Florida. Botanically, S. racemosa is diploid with 18 chromosomes, and flow cytometry data indicated that S. baicalensis and S. racemosa have small nuclei with estimated small genomes (377 mbp and 411 mbp respectively). Antioxidant potential studies showed that there were no significant differences in the 3 Scutellaria species. Phytochemical analyses detected and quantified the flavonoids baicalin, baicalein, scutellarin, and wogonin as well as the human neurohormones melatonin and serotonin in leaf and stem tissues from S. baicalensis, S. lateriflora, and S. racemosa. These findings represent the first phytochemical analysis of S. racemosa and establish S. racemosa as a model system for study of medicinal plant secondary metabolism and as a potential source of important phytopharmaceuticals for treatment of human disease.