Plasma levels of insulin-like growth factor-1 and binding protein-3, and their association with bladder cancer risk
Plasma levels of insulin-like growth factor-1 and binding protein-3, and their association with bladder cancer risk
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DOI：
10.1016/s0022-5347(05)63999-7
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发表时间：
2003-02-01
影响因子：
6.6
通讯作者：
Wu, XF
中科院分区：
文献类型：
--
作者：
Zhao, H;Grossman, HB;Wu, XF
目的：由于胰岛素样生长因子（JGFs）及其结合蛋白与前列腺癌、乳腺癌、结肠癌和肺癌的发展有关，我们研究了IGF-1和IGF结合蛋白-3水平在膀胱癌风险中的作用。材料和方法：我们使用酶联免疫吸附法比较154例膀胱癌患者和154例对照患者血浆中IGF-1和IGF结合蛋白-3的水平。结果：病例中IGF-1的平均值明显高于对照组（175.8 ng./ml vs 153.2 ng./ml）。， p < 0.01)。病例中IGF结合蛋白-3的平均值显著低于对照组（2632.9 ng./ml vs 3056.6 ng./ml）。p
Purpose: Because insulin-like growth factors JGFs) and their binding proteins have been implicated in the development of prostate, breast, colon and lung cancer, we examined the role of IGF-1 and IGF binding protein-3 levels in bladder cancer risk.Materials and Methods: We used an enzyme-linked immunosorbent assay to compare plasma levels of IGF-1 and IGF binding protein-3 in 154 patients with bladder cancer and 154 controls from an ongoing case-control study.Results: Mean IGF-1 was significantly higher in cases than in controls (175.8 versus 153.2 ng./ml., p < 0.01). Mean IGF binding protein-3 was significantly lower in cases than in controls (2,632.9 versus 3,056.6 ng./ml., p