Possible alternative therapies for oral lichen planus cases refractory to steroid therapies
Possible alternative therapies for oral lichen planus cases refractory to steroid therapies
复制标题
类固醇治疗难治性口腔扁平苔藓病例的可能替代疗法
DOI：
10.1016/j.oooo.2016.02.002
复制
发表时间：
2016-05-01
影响因子：
2.9
通讯作者：
Chen, Qianming
中科院分区：
文献类型：
--
作者：
Yang, Huamei;Wu, Yuanqin;Chen, Qianming
口腔扁平苔藓是一种多因素致病的慢性炎症性疾病。免疫失调在这种疾病的发展和进展中起着至关重要的作用。萎缩-糜烂性病变引起的疼痛可能影响患者的生活。由于病因不明，治疗通常是对症的。局部类固醇仍然是治疗的主要手段。然而，它们的治疗益处并不总是明显的。有大量的数据，可能的治疗策略是有效的OLP病例难治性类固醇。本文综述了目前激素难治性OLP的治疗方法。各种治疗方案包括他克莫司、吡美莫司、沙利度胺、低强度激光治疗、光动力治疗和手术切除。从这些研究中获得的一些结果是有希望的。但是，需要进一步的研究，特别是具有严格的纳入和排除标准和较大样本量的随机对照试验，以评估这些疗法的长期安全性和有效性。
Oral lichen planus (OLP) is a chronic inflammatory disorder with a multifactorial etiopathogenesis. Immune dysregulation plays a critical role in the development and progression of this disease. Patients' lives may be affected by pain caused by atrophic-erosive lesions. Given the obscure etiology, treatment is usually symptomatic. Topical steroids remain the mainstay of management. However, their therapeutic benefits are not always evident. There are substantial data on the possible therapeutic strategies that are effective in OLP cases refractory to steroids. This review provides an overview of the current approaches for the management of steroid-refractory OLP. The miscellaneous treatment regimens include tacrolimus, pimecrolimus, thalidomide, low-level laser therapy, photodynamic therapy, and surgical excision. Some results obtained from these studies were promising. However, further studies, especially randomized controlled trials with strict inclusion and exclusion criteria and larger sample sizes, are required for the evaluation of the long-term safety and efficacy of these therapies.