Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments.
Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments.
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DOI：
10.1242/dmm.007724
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发表时间：
2011-11
影响因子：
4.3
通讯作者：
Feron O
中科院分区：
文献类型：
--
作者：
Draoui N;Feron O
低氧和癌基因的表达都会刺激肿瘤的糖酵解代谢，从而导致乳酸的产生。然而，乳酸不仅仅是糖酵解的副产品：它可以被氧化的癌细胞用作代谢燃料。这种现象类似于已描述的骨骼肌和大脑的过程，涉及众所周知的细胞-细胞和细胞内乳酸穿梭。有两个控制点调节乳酸穿梭：依赖乳酸脱氢酶(LDH)将乳酸转化为丙酮酸(来回)，以及通过特定的单羧酸转运体(MCT)将乳酸运入和运出细胞。在肿瘤中，MCT4主要参与低氧驱动的乳酸释放，而肿瘤细胞和肿瘤内皮细胞摄取乳酸是通过MCT1实现的。将乳酸穿梭的知识转化到癌症领域为治疗缺氧的肿瘤微环境和解决肿瘤血管生成提供了新的视角。
Hypoxia and oncogene expression both stimulate glycolytic metabolism in tumors, thereby leading to lactate production. However, lactate is more than merely a by-product of glycolysis: it can be used as a metabolic fuel by oxidative cancer cells. This phenomenon resembles processes that have been described for skeletal muscle and brain that involve what are known as cell-cell and intracellular lactate shuttles. Two control points regulate lactate shuttles: the lactate dehydrogenase (LDH)-dependent conversion of lactate into pyruvate (and back), and the transport of lactate into and out of cells through specific monocarboxylate transporters (MCTs). In tumors, MCT4 is largely involved in hypoxia-driven lactate release, whereas the uptake of lactate into both tumor cells and tumor endothelial cells occurs via MCT1. Translating knowledge of lactate shuttles to the cancer field offers new perspectives to therapeutically target the hypoxic tumor microenvironment and to tackle tumor angiogenesis.
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DOI：
10.1016/s0305-0491(98)00025-x
发表时间：
1998-05-01
影响因子：
2.2
作者：
Brooks, GA
通讯作者：
Brooks, GA
影响因子：
15.9
作者：
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影响因子：
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影响因子：
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作者：
Bonuccelli, Gloria;Tsirigos, Aristotelis;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.
影响因子：
11.2
作者：
Koukourakis, MI;Giatromanolaki, A;Sivridis, E
通讯作者：
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