Tf 2 O‐Mediated Regioselective C(sp 2 )−H Sulfenylation of Enaminones Using Methyl Sulfoxides as Sulfur Sources
Tf 2 O‐Mediated Regioselective C(sp 2 )−H Sulfenylation of Enaminones Using Methyl Sulfoxides as Sulfur Sources
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Tf 2 O–介导的以甲基亚砜为硫源的烯胺酮区域选择性 C(sp 2 )–H 磺酰化
DOI：
10.1002/ajoc.202200014
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发表时间：
2022
影响因子：
2.7
通讯作者：
Wei Wang
中科院分区：
文献类型：
--
作者：
Changyuan Zhang;Jian Luo;Jiantao Zhang;Lulu Chen;Xuncheng Zhu;Mengping Guo;Chan Shen;Zeng Li;Wei Wang
已经描述了一种有效的Tf 2 O介导的烯胺酮的区域选择性C（sp2）−H亚磺酰基化。以甲基亚砜为硫源，在温和的反应条件下与不同类型的烯胺酮反应，提供了一种直接合成β-氨基硫醚的方法，收率高达97%。此外，这种亚磺酰化在无氧化剂和无金属的情况下顺利进行。
An efficient Tf2O‐mediated regioselective C(sp2)−H sulfenylation of enaminones has been described. Methyl sulfoxides are employed as sulfur sources to react with different types of enaminones under mild reaction conditions, providing a straightforward approach for the synthesis of β‐amino sulfides in up to 97% yieldviaone‐pot manner. Moreover, this sulfenylation proceeded smoothly with oxidant‐free and metal‐free.