Ventral and dorsal visual pathways exhibit abnormalities of static and dynamic connectivities, respectively, in patients with schizophrenia
Ventral and dorsal visual pathways exhibit abnormalities of static and dynamic connectivities, respectively, in patients with schizophrenia
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精神分裂症患者的腹侧和背侧视觉通路分别表现出静态和动态连接异常
DOI：
10.1016/j.schres.2018.12.005
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发表时间：
2019-04-01
影响因子：
4.5
通讯作者：
Wen, Ge
中科院分区：
文献类型：
--
作者：
Deng, Yanjia;Liu, Kai;Wen, Ge
先前的研究表明，精神分裂症相关的视觉知觉异常主要归因于背侧视觉通路的缺陷，而不是腹侧视觉通路的缺陷。在这项研究中，我们比较探讨了精神分裂症患者的背侧和腹侧网络在静态和动态功能连接（FC）方面的变化。对40名精神分裂症患者和24名符合年龄和性别的健康对照者进行静息状态磁共振扫描。根据激活似然估计分析的结果坐标定义背侧和腹侧视觉网络。静态和动态网络特性分别基于全范围和分段血氧水平依赖时间序列计算。结果表明，在精神分裂症组中，静态FC和动态FC的腹侧和背侧视觉网络分别表现出异常。静态FC评估显示，精神分裂症患者的腹侧视觉网络聚类系数显著降低，特征路径长度缩短。背侧视觉网络的动态FC评估显示出更高的平均时间变异性（p = 0.026）和更高的右侧梭状回区域FC变异性（p = 0.026）
Previous studies suggest that schizophrenia-related visual perceptual abnormalities are primarily attributed to deficits of the dorsal rather than ventral visual pathway. In this study, we comparatively explored changes in dorsal and ventral networks in schizophrenia patients in both static and dynamic functional connectivity (FC). Resting-state MR scans were acquired for forty schizophrenia patients and twenty-four healthy controls matched for age and gender. The dorsal and ventral visual networks were defined based on the resultant coordinates from activation likelihood estimation analyses. Static and dynamic network properties were calculated based on the full-range and segmented blood oxygen level dependent time series, respectively. The results indicated that the ventral and dorsal visual networks exhibited abnormalities in static FC and dynamic FC, respectively, in the schizophrenia group. Static FC assessments in the ventral visual network showed a significantly decreased clustering coefficient and shortened characteristic path length in patients with schizophrenia. Dynamic FC assessments in the dorsal visual network showed significantly higher mean temporal variability (p = 0.026) and higher regional FC variability of the right fusiform gyros (p