Design, synthesis, and diversification of 5,5-dimethyl cyclohexen-1,4-dione library.
Design, synthesis, and diversification of 5,5-dimethyl cyclohexen-1,4-dione library.
复制标题
5,5-二甲基环己烯-1,4-二酮文库的设计、合成和多样化。
DOI：
10.1021/cc100030h
复制
发表时间：
2010
影响因子：
--
通讯作者：
Gilbertson,ScottR
中科院分区：
文献类型：
--
作者：
Tanifum,EricA;Gilbertson,ScottR
本文报道了利用Fischer卡宾配合物与炔烃的成环反应合成了78个内二酮。在工作过程中，合成了新的甲锡烷基和甲硅烷基endiones，并转化为碘化物，为Suzuki偶联提供了有用的前体。还对溴代苯基炔衍生的内二酮进行了Suzuki反应，得到了一系列新的环己烯-1，4-二酮。
This paper reports the use of the annulation reaction between Fischer carbene complexes and alkynes to provide a collection of 78 endiones. In the course of the work, new stannyl and silyl endiones were synthesized and converted to iodides that provide a useful precursor for Suzuki coupling. Suzuki reactions were also performed on endiones derived from bromophenyl alkynes providing a series of new cyclohexen-1,4-diones.