Evaluation of T1 relaxation time in prostate cancer and benign prostate tissue using a Modified Look-Locker inversion recovery sequence
Evaluation of T1 relaxation time in prostate cancer and benign prostate tissue using a Modified Look-Locker inversion recovery sequence
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DOI：
10.1038/s41598-020-59942-z
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发表时间：
2020-02-20
影响因子：
4.6
通讯作者：
Makowski, Marcus R.
中科院分区：
文献类型：
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作者：
Baur, Alexander D. J.;Hansen, Carla M.;Makowski, Marcus R.
本研究的目的是评估T1松弛时间（T1）在鉴别前列腺癌（PCa）与良性组织以及高级别与低级别前列腺癌中的诊断价值。本前瞻性研究纳入了23例疑似PCa的患者。获得3T MRI，包括改进的Look-Locker反转恢复序列。随后有针对性和系统的前列腺活检作为参考标准。采用Mann-Whitney U检验比较PCa与无恶性对照区、高分级和低分级PCa的T1和表观扩散系数（ADC）值。通过受试者工作特征（ROC）分析评估T1、ADC值以及两者结合区分PCa和参考区域的性能。PCa的T1和ADC值低于周边和过渡区的参考区域（p < 0.001）。ROC分析显示，在区分PCa和参考区域时，T1 （0.92; 95% ci, 0.87-0.98）和ADC值（0.97;95% ci, 0.94 - 1.0）的auc较高。T1和ADC值的组合产生更高的AUC。与单独ADC值的AUC比较，差异有统计学意义（p = 0.02）。高分级和低分级PCa的T1 （p = 0.31）和ADC值（p = 0.8）无显著差异。前列腺癌与良性前列腺组织T1松弛时间差异显著，前列腺癌T1较低。它可能是前列腺癌的一种成像生物标志物。
Purpose of this study was to evaluate the diagnostic performance of T1 relaxation time (T1) for differentiating prostate cancer (PCa) from benign tissue as well as high- from low-grade PCa. Twenty-three patients with suspicion for PCa were included in this prospective study. 3T MRI including a Modified Look-Locker inversion recovery sequence was acquired. Subsequent targeted and systematic prostate biopsy served as a reference standard. T1 and apparent diffusion coefficient (ADC) value in PCa and reference regions without malignancy as well as high- and low-grade PCa were compared using the Mann-Whitney U test. The performance of T1, ADC value, and a combination of both to differentiate PCa and reference regions was assessed by receiver operating characteristic (ROC) analysis. T1 and ADC value were lower in PCa compared to reference regions in the peripheral and transition zone (p < 0.001). ROC analysis revealed high AUCs for T1 (0.92; 95%-CI, 0.87-0.98) and ADC value (0.97; 95%-CI, 0.94 to 1.0) when differentiating PCa and reference regions. A combination of T1 and ADC value yielded an even higher AUC. The difference was statistically significant comparing it to the AUC for ADC value alone (p = 0.02). No significant differences were found between high- and low-grade PCa for T1 (p = 0.31) and ADC value (p = 0.8). T1 relaxation time differs significantly between PCa and benign prostate tissue with lower T1 in PCa. It could represent an imaging biomarker for PCa.