Lipoprotein subfractions of runners and sedentary men.
Lipoprotein subfractions of runners and sedentary men.
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DOI：
10.1016/0026-0495(86)90094-6
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
P. Williams;R. Krauss;P. Wood;F. Lindgren;C. Giotas;K. Vranizan
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文献类型：
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作者：
P. Williams;R. Krauss;P. Wood;F. Lindgren;C. Giotas;K. Vranizan
采用分析超速离心法测定了12名长跑运动员和64名久坐男性的血清脂蛋白质量浓度（以漂浮率计）。运动员具有显著较低的血清质量浓度的较小，密度低密度脂蛋白颗粒的浮动率Sf 0 -7（包括LDL-II、LDL-III和LDL-IV亚种）、Sf 20 -400的极低密度脂蛋白（VLDL）颗粒和漂浮率F1.200-1.5的高密度脂蛋白（HDL）颗粒（主要是HDL 3亚种），和更高的血清HDL颗粒的质量浓度，其浮动率在F 1.202.0 -9.0之间（包括HDL 2a和HDL 2b带属于HDL 3的密度较低的颗粒）。跑步者的脂蛋白脂肪酶活性高于久坐者，而肝脂肪酶活性低于久坐者。因此，耐力运动训练对降低LDL的影响可能是特定于更小，更密集的LDL颗粒区域。跑步者的脂蛋白质量分布与久坐的中年女性的低风险分布相似，这表明常见代谢因素的影响可能导致冠状动脉疾病风险降低。
Serum concentrations of lipoprotein mass by flotation rate were measured in 12 long-distance runners and 64 sedentary men by analytic ultracentrifugation. The runners had significantly lower serum mass concentrations of the smaller, denser low-density lipoprotein particles of flotation rates Sf0–7 (including the LDL-II, LDL-III, and LDL-IV subspecies), very-low-density lipoprotein (VLDL) particles of Sf20–400, and high-density lipoprotein (HDL) particles of flotation rates F1.200–1.5 (predominately the HDL3subspecies), and higher serum mass concentrations of HDL particles with flotation rates between F1.202.0–9.0 (including HDL2aand HDL2band less dense particles belonging to HDL3) than did sedentary men. Lipoprotein lipase activity was higher, and hepatic lipase activity was lower in runners than in the sedentary men. Thus, the affects of endurance exercise training to lower LDL may be specific to the smaller, denser LDL particle region. Similarities in the lipoprotein mass profiles of the runners and the low-risk profiles of sedentary, middle-aged women suggest the effects of common metabolic factors possibly leading to reduced risk of coronary artery disease.