The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats
The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats
复制标题
DOI：
10.1016/j.biomaterials.2004.02.072
复制
发表时间：
2005-02-01
期刊：
影响因子：
14
通讯作者：
Tanaka, T
中科院分区：
文献类型：
--
作者：
Kajiwara, H;Yamaza, T;Tanaka, T
许多具有不同表面的材料已被开发用于牙科和骨科的临床植入治疗。我们分析了体内钙固定钛种植体周围形成的新骨数量，这些种植体的表面用帕米膦酸盐（PAM）、含氮双膦酸盐（N-BP）、纯钛种植体和用钙离子固定的钛种植体进行了改性。植入后1周和3周，通过静脉注射荧光标记（钙黄绿素蓝和茜素络合酮）观察新骨形成。4周后，制备不脱钙切片，并使用共聚焦激光扫描显微镜图像通过形态测量法检查种植体周围的新骨形成。1周后，PAM固定的种植体周围形成的新骨比钙固定和纯钛种植体周围形成的新骨更多。3周后新骨形成也观察到了这一点。4周后，BP固定种植体周围形成的新骨明显多于钙离子植入种植体和纯钛种植体周围。新的N-BP改性钛表面刺激种植体周围的新骨形成，这可能有助于种植体治疗的成功。(C)2004爱思唯尔有限公司保留所有权利。
Many materials with differing surfaces have been developed for clinical implant therapy in dentistry and orthopedics. We analyzed the quantity of new bone formed in vivo around caleium-immobilized titanium implants with surfaces modified using pamidronate (PAM), a nitrogen-containing bisphosphonate (N-BP), implants of pure titanium, and titanium implants immobilized with calcium ions. New bone formation was visualized using fluorescent labeling (calcein blue and alizarin complexone) with intravenous injection at 1 and 3 weeks after implantation. After 4 weeks, undecalcified sections were prepared, and new bone formation around the implants was examined by morphometry using confocal laser scanning microscopy images. After 1 week, more new bone formed around the PAM-immobilized implant than around the calcium-immobilized and pure titanium implants. This was also seen with the new bone formation after 3 weeks. After 4 weeks, significantly more new bones were formed around the BP-immobilized implant than around the calcium ion-implanted and pure titanium implants. The new N-BP-modified titanium surface stimulates new bone formation around the implant, which might contribute to the success of implant therapy. (C) 2004 Elsevier Ltd. All rights reserved.