Relationship of C-reactive protein to risk of cardiovascular disease in the elderly - Results from the Cardiovascular Health Study and the Rural Health Promotion Project
Relationship of C-reactive protein to risk of cardiovascular disease in the elderly - Results from the Cardiovascular Health Study and the Rural Health Promotion Project
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DOI：
10.1161/01.atv.17.6.1121
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发表时间：
1997-06-01
影响因子：
8.7
通讯作者：
Kuller, LH
中科院分区：
文献类型：
--
作者：
Tracy, RP;Lemaitre, RN;Kuller, LH
炎症标志物，如c反应蛋白（CRP），与心绞痛患者心血管疾病（CVD）事件的风险相关，但对于没有常见临床CVD的个体知之甚少。我们在心血管健康研究（CHS； 5201名健康老年男性和女性）中进行了一项前瞻性、嵌套病例对照研究。病例受试者（n=146名发生心血管疾病事件的男性和女性，包括心绞痛、心肌梗死和死亡）和对照受试者（n=146名）根据性别和基线时是否存在显著的亚临床心血管疾病进行匹配（平均随访2.4年）。在女性而非男性中，病例组的平均CRP水平高于对照组（P小于或等于0.05）。总的来说，亚临床疾病患者CRP水平较高。与对照组相比，女性病例组CRP与亚临床疾病亚组的相关性最大：3.33 mg/L与1.90 mg/L， P
Markers of inflammation, such as C-reactive protein (CRP), are related to risk of cardiovascular disease (CVD) events in those with angina, but little is known about individuals without prevalent clinical CVD. We performed a prospective, nested case-control study in the Cardiovascular Health Study (CHS; 5201 healthy elderly men and women). Case subjects (n=146 men and women with incident CVD events including angina, myocardial infarction, and death) and control subjects (n=146) were matched on the basis of sex and the presence or absence of significant subclinical CVD at baseline (average follow-up, 2.4 years). In women but not men, the mean CRP lever was higher for case subjects than for control subjects (P less than or equal to.05). In general, CRP was higher in those with subclinical disease. Most of the association of CRP with female case subjects versus control subjects was in the subgroup with subclinical disease: 3.33 versus 1.90 mg/L, P