Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression.
Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression.
复制标题
细胞质 p63 表达增加乳腺上皮细胞的侵袭性和攻击性
DOI：
10.7150/ijbs.6.428
复制
发表时间：
2010-08-08
影响因子：
9.2
通讯作者：
Man YG
中科院分区：
文献类型：
--
作者：
Hsiao YH;Su YA;Tsai HD;Mason JT;Chou MC;Man YG
运动蛋白分子是一种能够通过水解ATP沿着微管运动的运动蛋白。它们通常有几种结构形式。这篇综述的重点是研究最多的两种形式：单体如KIF1A（激酶3家族）和二聚体如常规激酶1家族)，它们都可以向微管+端移动。现在有许多模型试图解释驱动蛋白分子如何将ATP水解的化学能转化为机械能，以“驱动”它们沿着微管的持续运动。在这里，我们试图对这些模型进行全面的回顾。在此基础上，我们进一步提出了二聚体动力蛋白的杂交模型，并为今后的研究提供了框架。
Kinesin molecules are motor proteins capable of moving along microtubule by hydrolyzing ATP. They generally have several forms of construct. This review focuses on two of the most studied forms: monomers such as KIF1A (kinesin-3 family) and dimers such as conventional kinesin (kinesin-1 family), both of which can move processively towards the microtubule plus end. There now exist numerous models that try to explain how the kinesin molecules convert the chemical energy of ATP hydrolysis into the mechanical energy to “power” their proceesive movement along microtubule. Here, we attempt to present a comprehensive review of these models. We further propose a new hybrid model for the dimeric kinesin by combining the existing models and provide a framework for future studies in this subject.