Visual chiral recognition of mandelic acid enantiomers with L-tartaric acid-capped gold nanoparticles as colorimetric probes
Visual chiral recognition of mandelic acid enantiomers with L-tartaric acid-capped gold nanoparticles as colorimetric probes
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L-酒石酸封端金纳米粒子作为比色探针视觉手性识别扁桃酸对映体
DOI：
10.1016/j.snb.2015.03.109
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Li Baoxin
中科院分区：
文献类型：
--
作者：
Song Guoxin;Xu Chunli;Li Baoxin
本文报道了一种直观区分扁桃酸（MA）的立体异构体和立体异构体的方法。它是基于1-酒石酸封端的金纳米颗粒（1-TA封端的AuNP，ca.直径13 nm），可用作MA的l-和d-形式的手性选择剂。在向thel-TA-封端的AuNP的溶液中添加fl-MA时，可以看到从红色到蓝色的颜色变化，而在添加d-MA时没有发现颜色变化。手性测定可用于测定-100%至100%范围内的对映体过量。该效果可以用裸眼检测并通过分光光度法定量。值得注意的是，该方法不需要复杂的手性修饰。该方法具有灵敏度高、成本低、原料易得、操作简便等优点。
We report a method for visual differentiation between thel- andd-forms of mandelic acid (MA). It is based on the chirality ofl-tartaric acid-capped gold nanoparticles (l-TA-capped AuNPs, ca. 13 nm in diameter) that can be used as chiral selector forl- andd-forms of MA. On addition ofl-MA to a solution of thel-TA-capped AuNPs, a color change from red to blue can be seen, while no color change is found on addition ofd-MA. The chiral assay can be used to determine the enantiomeric excess ofl-MA in the range from −100% to 100%. The effect can be detected with bare eyes and quantified by spectrophotometry. Notably, this method does not require the complicated chiral modification. The method excels by its sensitivity, low cost, good availability of materials, and its simplicity.