Neurotoxicity of MDMA (ecstasy):: the limitations of scaling from animals to humans
Neurotoxicity of MDMA (ecstasy):: the limitations of scaling from animals to humans
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DOI：
10.1016/j.tips.2004.08.001
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发表时间：
2004-10-01
影响因子：
13.8
通讯作者：
Farré, M
中科院分区：
文献类型：
--
作者：
de la Torre, R;Farré, M
一些研究表明，MDMA诱导的急性毒性和长期神经毒性取决于MDMA的代谢处置。因此，动物物种间MDMA代谢的差异可能是对其神经毒性效应敏感性不同的原因。调节MDMA神经毒性代谢物形成的酶的动力学参数因物种而异，MDMA自我抑制这些酶的能力以及这些酶表现出的遗传多态性程度也各不相同。这些特征限制了动物模型的异速生长比例。
Several studies suggest that MDMA-induced acute toxicity and long-term neurotoxicity is dependent on the metabolic disposition of MDMA. Differences in MDMA metabolism among animal species might therefore account for different sensitivities to its neurotoxic effects. The kinetic parameters of enzymes that regulate the formation of neurotoxic metabolites of MDMA differ among species, as does the ability of MDMA to self-inhibit these enzymes and the degree of genetic polymorphisms exhibited by these enzymes. Such features limit allometric scaling across animal models.