The Drosophila calcineurin regulator, Sarah, is involved in male courtship
The Drosophila calcineurin regulator, Sarah, is involved in male courtship
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DOI：
10.1097/wnr.0b013e32833eaade
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发表时间：
2010-10
期刊：
影响因子：
1.7
通讯作者：
T. Sakai;T. Aigaki
中科院分区：
文献类型：
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作者：
T. Sakai;T. Aigaki
果蝇萨拉（sra）基因编码Ca2+/钙调素依赖性蛋白磷酸酶，钙调神经磷酸酶的调节因子，并在各种生物过程中发挥重要作用。在这里，我们描述了sra在果蝇雄性求偶行为中的新作用。Sra零突变雄性的求偶活动减少。这种减少的活性可以通过在蘑菇体（mb）中表达sra来恢复，蘑菇体是果蝇记忆形成和储存的重要大脑结构。此外，在MBs中过表达sra，以及在成年期短暂过表达sra，会抑制雄性求偶。我们的研究结果表明，野生型雄性求偶活动需要MBs中特定数量的sra。
The Drosophila Sarah (sra) gene encodes a regulator of the Ca2+/calmodulin-dependent protein phosphatase, calcineurin, and plays an essential role in various biological processes. Here, we describe a novel role of sra in Drosophila male courtship behavior. sra null mutant males have reduced courtship activity. This reduced activity can be rescued by expressing sra in the mushroom bodies (MBs), brain structures important for memory formation and storage in Drosophila. In addition, overexpressing sra in the MBs, and transiently overexpressing sra during adulthood, inhibits male courtship. Our results indicate that a specific amount of sra in the MBs is required for wildtype male courtship activity.