Long-term prognosis of cerebral vein and dural sinus thrombosis
Long-term prognosis of cerebral vein and dural sinus thrombosis
复制标题
DOI：
10.1159/000057855
复制
发表时间：
2002-01-01
影响因子：
2.9
通讯作者：
Fontes, J
中科院分区：
文献类型：
--
作者：
Ferro, JM;Lopes, MG;Fontes, J
本研究的目的是分析葡萄牙医院收治的脑静脉和硬脑膜窦血栓形成（CVDST）的长期死亡率、功能恢复和长期并发症。对自1980年以来在葡萄牙医院住院的有症状的CVDST进行了随访。1996年期间对51例患者（回顾性病例）进行了重新评价;对1995年6月至1998年6月期间连续入院的91例患者进行了随访，直至1999年。1996年，4例（8%）回顾性病例死亡（3例患者死于急性期），4例（8%）无法联系，33例（64%）完全恢复（兰金0或1），3例（6%）依赖。前瞻性病例的平均随访时间为1年：6例（7%）患者在急性期死亡，1例（1%）患者在随访期间死亡，75例（82%）患者完全恢复，仅1例（1%）患者依赖。对于前瞻性病例，入院后恶化（OR = 18.2; 95%CI = 2.9-112.4）和脑病为首发症状（OR = 7.1; 95%CI = 1.2-40.9）预测死亡或依赖，而无失语症（OR 6.7，95% CI = 1.6-33）和入院后无恶化（OR = 5.9; 95% CI = 1.6-20）预测完全恢复。在前瞻性病例的随访期间，4例（5%）患者发生血栓形成事件，8例（10%）患者发生癫痫发作，9例（11%）患者主诉严重头痛，1例患者发生严重视力丧失。CVDST患者的长期功能预后相当好，大多数病例完全恢复。然而，这些患者发生进一步血栓形成事件和癫痫发作的风险为中度。版权所有（C）2002 S. Karger AG，巴塞尔。
The purpose of this study was to analyze the long-term mortality, functional recovery and long-term complications of cerebral vein and dural sinus thrombosis (CVDST) admitted to Portuguese hospitals. A follow-up of symptomatic CVDST admitted to Portuguese hospitals since 1980 was performed. Fifty-one patients (retrospective cases) were re-evaluated during 1996; 91 consecutively admitted patients from 6/1995 to 6/1998 were followed up to 1999. In 1996, 4 (8%) of the retrospective cases had died (3 patients died in the acute phase), 4 (8%) could not be reached, 33 (64%) had recovered completely (Rankin 0 or 1) and 3 (6%) were dependent. The prospective cases had a mean follow-up of 1 year: 6 (7%) patients died in the acute phase, one (1%) died during follow-up, 75 (82%) recovered completely, and only 1 (1%) was dependent. For the prospective cases, worsening after admission (OR = 18.2; 95% CI = 2.9-112.4) and encephalopathy as the presenting syndrome (OR = 7.1; 95% CI = 1.2-40.9) predicted death or dependency, while absence of aphasia (OR 6.7, 95% CI = 1.6-33) and no worsening after admission (OR = 5.9; 95% CI = 1.6-20) predicted total recovery. During follow-up of the prospective cases, 4 (5%) patients had thrombotic events, 8 (10%) patients experienced seizures, 9 (11%) complained of severe headaches and 1 patient suffered severe visual loss. The long-term functional prognosis of patients with CVDST was fairly good with complete recovery in the majority of cases. However, these patients had a moderate risk of further thrombotic events and seizures. Copyright (C) 2002 S. Karger AG, Basel.