Long-term clinical follow-up of a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies
Long-term clinical follow-up of a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies
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DOI：
10.1016/j.jneuroim.2018.04.001
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发表时间：
2018-06-15
影响因子：
3.3
通讯作者：
Shimohata, Takayoshi
中科院分区：
文献类型：
--
作者：
Yoshikura, Nobuaki;Kimura, Akio;Shimohata, Takayoshi
与抗代谢型谷氨酸受体1（mGluR1）自身抗体相关的小脑性共济失调的临床特征，一种罕见的自身免疫介导的小脑性共济失调，仍有待阐明。在这里，我们描述了一个非副肿瘤性小脑共济失调与抗mGluR1自身抗体，谁是随访超过5年。她表现为对免疫治疗有反应的亚急性进行性小脑共济失调复发和缓解。尽管持续检测到血清抗mGluR1自身抗体，小脑萎缩逐渐进展，但反复静脉注射免疫球蛋白治疗和口服免疫抑制剂确保小脑共济失调在观察期间保持在几乎相同的水平。
The clinical features of cerebellar ataxia associated with anti-metabotropic glutamate receptor 1 (mGluR1) autoantibodies, a rare autoimmune-mediated cerebellar ataxia, remain to be elucidated. Here, we describe a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies, who was followed up over 5 years. She presented with relapses and remissions of subacute progressive cerebellar ataxia that were responsive to immunotherapy. Although serum anti-mGluR1 autoantibodies were continuously detected and cerebellar atrophy gradually progressed, repeated intravenous immunoglobulin therapy and oral immunosuppressants ensured cerebellar ataxia remained at almost the same level during the observation period.