Sexually dimorphic hemodynamic effects of intragastric ethanol in conscious rats
Sexually dimorphic hemodynamic effects of intragastric ethanol in conscious rats
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DOI：
10.3109/10641969909070858
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发表时间：
1999-11-01
影响因子：
12.3
通讯作者：
Abdel-Rahman, AA
中科院分区：
文献类型：
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作者：
El-Mas, MM;Abdel-Rahman, AA
本研究探讨了小剂量至中等剂量灌胃乙醇对清醒大鼠血流动力学影响的性别差异。观察乙醇（0.25、0.5或1 g/kg）诱发的平均动脉压（MAP）、心率、心脏指数（CT）、脑卒中容积（SV）和总外周阻力（TPR）的变化，观察时间为90 min。MAP基线值（121+/-2 vs 124+/-2 mmHg）相似，而CI （55+/-2 vs 43+/-2 ml/min/ 100g）和TPR （2.2+/-0.1 vs 3.0+/-0.1 mmHg/ml/min/ 100g）差异显著(P
This study investigated the gender-related differences in hemodynamic effects of small to moderate doses of intragastrically (i.g.) administered ethanol in conscious rats. Changes evoked by ethanol (0.25, 0.5 or 1 g/kg) in mean arterial pressure (MAP), heart rate, cardiac index (CT), stroke volume (SV), and total peripheral resistance (TPR) were followed for 90 min in age-matched male and female Sprague-Dawley rats. Baseline values of MAP (121+/-2 vs 124+/-2 mmHg) were similar whereas CI (55+/-2 vs 43+/-2 ml/min/100 g) and TPR (2.2+/-0.1 vs 3.0+/-0.1 mmHg/ml/min/100 g) were significantly (P