Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation.
Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation.
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DOI：
10.1038/jid.2008.354
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发表时间：
2009-05
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影响因子：
--
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Consumption of green tea polyphenols (GTPs) in drinking water prevents photocarcinogenesis in mice; however, the molecular mechanisms underlying this effect have not been fully elucidated. Using interleukin (IL)-12p40 knockout (IL-12-KO) mice and their wild-type counterparts and an established photocarcinogenesis protocol, we found that although administration of GTPs (0.2%, w/v) in drinking water significantly reduced UVB-induced tumor development in wild-type mice, this treatment had a non-significant effect in IL-12-KO mice. GTPs resulted in reduction in the levels of markers of inflammation (COX-2, PGE2, PCNA, cyclin D1) and proinflammatory cytokines (TNF-α, IL-6, IL-1β) in chronically UVB-exposed skin and skin tumors of wild-type mice but less effective in IL-12p40-KO mice. UVB-induced DNA damage (cyclobutane pyrimidine dimers) was resolved rapidly in GTPs-treated wild-type mice than untreated wild-type mice and this resolution followed the same time course as the GTPs-induced reduction in the levels of inflammatory responses. This effect of GTPs was less pronounced in IL-12-KO mice. The above results were confirmed by treatment of IL-12-KO mice with murine rIL-12 and treatment of wild-type mice with neutralizing anti-IL-12 antibody. To our knowledge this is previously unreported that prevention of photocarcinogenesis by GTPs is mediated through IL-12-dependent DNA repair and a subsequent reduction in skin inflammation.
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DOI：
10.1084/jem.170.4.1117
发表时间：
1989-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Applegate LA;Ley RD;Alcalay J;Kripke ML
通讯作者：
Kripke ML
影响因子：
4.7
作者：
Buckman, SY;Gresham, A;Pentland, AP
通讯作者：
Pentland, AP
影响因子：
4.7
作者：
Katiyar, SK;Challa, A;Mukhtar, H
通讯作者：
Mukhtar, H
影响因子：
7.4
作者：
Katiyar, Santosh K.;Meeran, Syed M.
通讯作者：
Meeran, Syed M.
影响因子：
4.7
作者：
Pentland, AP;Schoggins, JW;Han, RJ
通讯作者：
Han, RJ