Edinburgh Research Explorer Stability of within-host–parasite communities in a wild mammal system
Edinburgh Research Explorer Stability of within-host–parasite communities in a wild mammal system
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爱丁堡研究探索者野生哺乳动物系统中宿主寄生虫群落的稳定性
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通讯作者：
J. W. Lewis
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作者：
J. Behnke;F. Gilbert;Marawan Abu;J. W. Lewis
主要来自观察性研究，这些研究在检测相互作用方面可能不可靠。我们在野生小鼠中进行了干扰实验，通过使用驱虫剂抑制线虫，并监测其他寄生虫物种的后果。总体而言，这些寄生虫群落是非常稳定的扰动。只有一个非目标寄生虫物种响应驱虫，这种反应是暂时的：我们发现强大的，但短暂的，增加了艾美球虫原虫的丰度，这与占主导地位的线虫物种共享一个感染部位，这表明当地的，动态的竞争。这些结果为野生脊椎动物中蠕虫和共感染寄生虫之间的相互作用提供了罕见而明确的实验证明，为了解人类和动物中类似药物治疗的更广泛后果迈出了重要一步。
primarily from observational studies, which may be unreliable at detecting interactions. We performed a perturbation experiment in wild mice, by using an anthelminthic to suppress nematodes, and monitored the consequences for other parasite species. Overall, these parasite communities were remarkably stable to perturbation. Only one non-target parasite species responded to deworming, and this response was temporary: we found strong, but short-lived, increases in the abundance of Eimeria protozoa, which share an infection site with the dominant nematode species, suggesting local, dynamic competition. These results, providing a rare and clear experimental demonstration of interactions between helminths and co-infecting parasites in wild vertebrates, constitute an important step towards understanding the wider consequences of similar drug treatments in humans and animals.