INTESTINAL-ABSORPTION OF FRUCTOSE IN THE RAT
INTESTINAL-ABSORPTION OF FRUCTOSE IN THE RAT
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DOI：
10.1016/0016-5085(91)90012-a
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发表时间：
1991-08-01
期刊：
影响因子：
29.4
通讯作者：
KRETCHMER, N
中科院分区：
文献类型：
--
作者：
FUJISAWA, T;RIBY, J;KRETCHMER, N
本研究的目的是探讨肠道吸收果糖的机制。结果表明，成年大鼠容易吸收0.4 g果糖，相当于1.4-1.6 g果糖/kg体重。剂量> 0.6 g（2.1-2.4 g/kg体重）时发生果糖急性吸收不良。持续暴露于膳食果糖导致结肠发酵的证据减少。葡萄糖或半乳糖与果糖一起给药可增强果糖的吸收。当同时给予等量的果糖和葡萄糖时，观察到最大的吸收。如果葡萄糖作为聚合物（淀粉或糊精）摄入，则刺激作用取决于聚合物的消化率。与果糖和葡萄糖一起给予的蔗糖减少了果糖的吸收。阿卡波松是α-葡萄糖醛酸酶（包括蔗糖酶）的特异性抑制剂，它也能抑制葡萄糖和半乳糖对果糖吸收的促进作用。这些结果为果糖和葡萄糖这两种单糖的联合吸收提供了证据。
The objective of this study was to investigate the mechanisms involved in intestinal absorption of fructose. The results indicate that adult rats readily absorbed 0.4 g of fructose, an amount equivalent to 1.4–1.6 g fructose/kg body wt. Acute malabsorption of fructose occurred with doses > 0.6 g (2.1–2.4 g/kg body wt). Continued exposure to dietary fructose resulted in a decrease in the evidence of colonic fermentation. Glucose or galactose administered with fructose enhanced the absorption of fructose. The greatest absorption was observed when equal amounts of fructose and glucose were given simultaneously. If glucose was ingested as a polymer (starch or dextrin), the stimulatory effect was dependent on the digestibility of the polymer. Sucrose given with the fructose and glucose diminished the absorption of fructose. Acarbazone, a specific inhibitor of α-glucosidases, including sucrase, also inhibited the facilitating effect of glucose and galactose in absorption of fructose. These results give evidence for joint absorption of the two monosaccharides, fructose and glucose.