A candidate packaging signal of human rotavirus differentiating Wa-like and DS-1-like genomic constellations.
A candidate packaging signal of human rotavirus differentiating Wa-like and DS-1-like genomic constellations.
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人类轮状病毒区分 Wa 样和 DS-1 样基因组星座的候选包装信号。
DOI：
10.1111/1348-0421.12288
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发表时间：
2015
影响因子：
2.6
通讯作者：
Yoshiyuki Suzuki
中科院分区：
文献类型：
--
作者：
Chantal A. Agbemabiese;Toyoko Nakagomi;Yoshiyuki Suzuki;George Armah;and Osamu Nakagomi;Yoshiyuki Suzuki
轮状病毒（RVA）具有11个片段rna的基因组。在人类RVA中，两个主要的基因组群由原型菌株Wa和DS‐1代表。本研究通过分析Wa - like和DS - 1 - like菌株的基因组序列，寻找区分Wa - like和DS - 1 - like基因组星座的包装信号。在病毒结构蛋白（VP） 2和VP6的编码区发现一对11个核苷酸位点在Wa‐样菌株中特异性互补。这些位点在基因组片段的二级结构中往往没有碱基配对，这表明它们可能在Wa - like菌株中作为包装信号。
RotavirusA(RVA) possesses a genome of 11 segmented RNAs. In human RVA, two major genomic constellations are represented by prototype strains Wa and DS‐1. Here packaging signals differentiating Wa‐like and DS‐1‐like genomic constellations were searched for by analyzing genomic sequences of Wa‐like and DS‐1‐like strains. One pair of 11 nucleotide sites in the coding regions of viral structural protein (VP) 2 and VP6 was found to be complementary specifically among Wa‐like strains. These sites tended to be free from base‐pairing in secondary structures of genomic segments, suggesting that they may serve as a packaging signal in Wa‐like strains.