Effects of Acute and Chronic Murine Norovirus Infections on Immune Responses and Recovery from Friend Retrovirus Infection
Effects of Acute and Chronic Murine Norovirus Infections on Immune Responses and Recovery from Friend Retrovirus Infection
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DOI：
10.1128/jvi.01445-09
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发表时间：
2009-12-15
影响因子：
5.4
通讯作者：
Hasenkrug, Kim J.
中科院分区：
文献类型：
--
作者：
Ammann, Christoph G.;Messer, Ronald J.;Hasenkrug, Kim J.
小鼠诺如病毒（MNV）是一种高度传染性但通常非致病性的病原体，在北美和欧洲的研究小鼠菌落中很常见。在本研究中，研究了急性和慢性MNV感染对并发Friend病毒（FV）感染的免疫反应和恢复的影响。在t细胞或nk细胞反应、FV中和抗体反应或FV感染的长期恢复方面没有观察到显著差异。我们得出结论，并发MNV感染对FV感染没有重大影响。
Murine norovirus (MNV) is a highly infectious but generally nonpathogenic agent that is commonly found in research mouse colonies in both North America and Europe. In the present study, the effects of acute and chronic infections with MNV on immune responses and recovery from concurrent Friend virus (FV) infections were investigated. No significant differences in T-cell or NK-cell responses, FV-neutralizing antibody responses, or long-term recovery from FV infection were observed. We conclude that concurrent MNV infections had no major impacts on FV infections.