Characterization of granuloma T lymphocyte function from Schistosoma mansoni-infected mice.
Characterization of granuloma T lymphocyte function from Schistosoma mansoni-infected mice.
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DOI：
10.4049/jimmunol.142.9.3239
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发表时间：
1989-05
影响因子：
4.4
通讯作者：
S. Ragheb;D. Boros
中科院分区：
文献类型：
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作者：
S. Ragheb;D. Boros
本研究旨在探讨曼氏血吸虫感染小鼠肝脏肉芽肿中T淋巴细胞功能的变化。虽然两种类型的病变含有相同百分比的T淋巴细胞，T细胞亚群分布是不同的。对于剧烈病变，辅助/效应T细胞与抑制/细胞毒性T细胞的比例为2至3：1。对于调制病变，该比率较低（1：1）。活力和调制肉芽肿（Gr）T细胞的表型特征的差异反映在其功能活性。充满活力的Gr T细胞在淋巴细胞增殖、IL-2产生和肉芽肿形成中比那些来自调制病变的更活跃。此外，调制的Gr T细胞抑制的功能活性的蓬勃Gr T细胞的剂量依赖性的方式。T细胞亚群的选择性清除表明，表型上，Gr迟发型超敏反应T细胞是L3 T4+，Lyt-1+，而Gr Ts细胞是Lyt-2+淋巴细胞。这两种T细胞亚群都存在于剧烈和调制的病变中。在急性感染期间，迟发型超敏反应T细胞淋巴细胞功能占主导地位，而Ts淋巴细胞功能似乎在慢性感染期间占上风。
This study was undertaken to characterize and compare T lymphocyte function from the vigorous and modulated liver granulomas of Schistosoma mansoni-infected mice. Although both types of lesion contained equal percentages of T lymphocytes, the T cell subset distribution was different. For vigorous lesions, the ratio of helper/effector to suppressor/cytotoxic T cells was 2 to 3:1. For modulated lesions the ratio was lower (1:1). Differences in the phenotypic profiles of vigorous and modulated granuloma (Gr) T cells were reflected in their functional activity. Vigorous Gr T cells were more active in lymphoproliferation, IL-2 production, and granuloma formation than those from modulated lesions. Moreover, modulated Gr T cells suppressed the functional activity of vigorous Gr T cells in a dose-dependent manner. The selective depletion of T cell subsets showed that phenotypically, the Gr delayed-hypersensitivity T cell is L3T4+, Lyt-1+ whereas the Gr Ts cell is an Lyt-2+ lymphocyte. Both of these T cell subsets are present in vigorous and modulated lesions. During acute infection, delayed-hypersensitivity T cell lymphocyte functions predominate, whereas Ts lymphocyte functions appear to prevail during chronic infection.