Changes of liver enzymes and triglyceride during the menopausal transition in Japanese women
Changes of liver enzymes and triglyceride during the menopausal transition in Japanese women
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DOI：
10.3109/01443615.2016.1154516
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发表时间：
2016-05
影响因子：
1.3
通讯作者：
S. Matsui;T. Yasui;K. Kasai;K. Keyama;Takeshi Kato;H. Uemura;A. Kuwahara;T. Matsuzaki;M. Irahara
中科院分区：
文献类型：
--
作者：
S. Matsui;T. Yasui;K. Kasai;K. Keyama;Takeshi Kato;H. Uemura;A. Kuwahara;T. Matsuzaki;M. Irahara
我们研究了肝酶作为代谢综合征和非酒精性脂肪性肝病（NAFLD）的替代标志物在绝经过渡期的详细变化，以及肝酶与代谢综合征和内分泌激素风险相关的血脂谱的相关性。我们根据月经规律、卵泡刺激素水平和绝经年限将393名妇女分为七个阶段。测定血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、γ-谷氨酰转移酶、血脂参数、血糖和内分泌激素水平。AST和ALT水平均在绝经后早期升高。AST在绝经后期仍然很高，但ALT下降。AST/ALT比值在绝经过渡晚期和绝经后极早期下降，此后升高。该比值与甘油三酯呈负相关。绝经过渡期ALT和AST/ALT比值的显著变化与甘油三酯相关，可能与日本女性代谢综合征和NAFLD的发生有关。
We examined detailed changes in liver enzymes as surrogate markers for metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) during the menopausal transition and the associations of liver enzymes with lipid profiles related to risk of metabolic syndrome and endocrinological hormones. We divided 393 women into seven stages by menstrual regularity, follicle-stimulating hormone level and years since menopause. Serum levels of alanine aminotranferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase, lipid parameters, glucose, and endocrinological hormones were measured. Both levels of AST and ALT increased towards early post-menopause. AST remained high in late post-menopause but ALT decreased. The AST/ALT ratio decreased towards late menopausal transition and very early post-menopause and increased thereafter. This ratio was negatively correlated with triglyceride. Significant changes in ALT and AST/ALT ratio during the menopausal transition, which were associated with triglyceride, might be involved in the occurrence of metabolic syndrome and NAFLD in Japanese women.