Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure.
Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure.
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DOI：
10.1159/000489095
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发表时间：
2018
影响因子：
4.2
通讯作者：
Eaton CB
中科院分区：
文献类型：
--
作者：
Bostom A;Steubl D;Garimella PS;Franceschini N;Roberts MB;Pasch A;Ix JH;Tuttle KR;Ivanova A;Shireman T;Kim SJ;Gohh R;Weiner DE;Levey AS;Hsu CY;Kusek JW;Eaton CB
Uromodulin is a kidney-derived glycoprotein and putative tubular function index. Lower serum uromodulin was recently associated with increased risk for kidney allograft failure in a preliminary, longitudinal single-center European study involving 91 kidney transplant recipients (KTRs). The Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial is a completed, large, multiethnic controlled clinical trial cohort, which studied chronic, stable KTRs. We conducted a case cohort analysis using a randomly selected subset of patients (random subcohort, n = 433), and all individuals who developed kidney allograft failure (cases, n = 226) during follow-up. Serum uromodulin was determined in this total of n = 613 FAVORIT trial participants at randomization. Death-censored kidney allograft failure was the study outcome. The 226 kidney allograft failures occurred during a median surveillance of 3.2 years. Unadjusted, weighted Cox proportional hazards modeling revealed that lower serum uromodulin, tertile 1 vs. tertile 3, was associated with a threefold greater risk for kidney allograft failure (hazards ratio [HR], 95% CI 3.20 [2.05–5.01]). This association was attenuated but persisted at two-fold greater risk for allograft failure, after adjustment for age, sex, smoking, allograft type and vintage, prevalent diabetes mellitus and cardiovascular disease (CVD), total/high-density lipoprotein cholesterol ratio, systolic blood pressure, estimated glomerular filtration rate, and natural log urinary albumin/creatinine: HR 2.00, 95% CI (1.06–3.77). Lower serum uromodulin, a possible indicator of less well-preserved renal tubular function, remained associated with greater risk for kidney allograft failure, after adjustment for major, established clinical kidney allograft failure and CVD risk factors, in a large, multiethnic cohort of long-term, stable KTRs.
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影响因子：
8.8
作者：
Foster, M. C.;Weiner, D. E.;Levey, A. S.
通讯作者：
Levey, A. S.
影响因子：
6.2
作者：
Jarolim, Petr;Claggett, Brian L.;Pfeffer, Marc A.
通讯作者：
Pfeffer, Marc A.
影响因子：
4.2
作者：
Reznichenko, Anna;van Dijk, Marcory C. R. F.;Navis, Gerjan
通讯作者：
Navis, Gerjan
影响因子：
4
作者：
Sanderson J;Thompson SG;White IR;Aspelund T;Pennells L
通讯作者：
Pennells L
影响因子：
37.8
作者：
Bostom AG;Carpenter MA;Kusek JW;Levey AS;Hunsicker L;Pfeffer MA;Selhub J;Jacques PF;Cole E;Gravens-Mueller L;House AA;Kew C;McKenney JL;Pacheco-Silva A;Pesavento T;Pirsch J;Smith S;Solomon S;Weir M
通讯作者：
Weir M