Cardiovascular response to trigeminal nerve stimulation at rest and during exercise in humans: does sex matter?
Cardiovascular response to trigeminal nerve stimulation at rest and during exercise in humans: does sex matter?
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DOI：
10.1152/ajpregu.00406.2017
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发表时间：
2018-02
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影响因子：
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通讯作者：
Eliza Prodel;T. Barbosa;A. Nóbrega;L. Vianna
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作者：
Eliza Prodel;T. Barbosa;A. Nóbrega;L. Vianna
我们试图调查的可能性，有性别差异的心血管反应三叉神经刺激（TGS）与冷暴露在休息和动态运动过程中的脸。在9名健康男性（年龄：28 ± 3岁;身高：178 ± 1 cm;重量：77 ± 8 kg）和13名女性（年龄26 ± 5岁;身高164 ± 3 cm;体重63 ± 7 kg）记录心跳心率（HR）和血压。计算平均动脉压（MAP）、每搏输出量（SV）、心脏指数（CI）和总血管阻力指数（TVRI）。在静息状态下应用TGS 3 min，并在心率为110次/min的10 min稳态自行车运动之间应用TGS，在每个周期的最后一分钟获得测量值。静息状态下，TGS增加两组的MAP（男性：Δ18 ± 8 mmHg;女性：Δ23 ± 8 mmHg;均值± SD）、TVRI（男性：Δ1.1 ± 0.6 mmHg·l-1·min·m-2;女性：Δ1.2 ± 1.2 mmHg·l-1·min·m-2）和SV（男性：Δ19 ± 15 ml;女性：Δ16 ± 11 ml）。CI在女性中随TGS而增加，但在男性中不增加。然而，男性对TGS的心动过缓反应（Δ-11 ± 8次/min）在女性中与基线相比并不显著。骑自行车运动增加男性和女性的HR，MAP，SV和CI，降低TVRI。运动期间TGS进一步增加了男性和女性的MAP，并且没有改变任何一组的CI。SV和TVRI增加TGS在运动过程中只有女性。运动期间TGS诱发男性心动过缓（Δ-7 ± 9次/min），而女性HR无变化。我们的研究结果表明，在休息和运动过程中，与TGS相关的心血管反应存在性别差异。
We sought to investigate the possibility that there are sex differences in the cardiovascular responses to trigeminal nerve stimulation (TGS) with cold exposure to the face at rest and during dynamic exercise. In 9 healthy men (age: 28 ± 3 yr; height: 178 ± 1 cm; weight: 77 ± 8 kg) and 13 women (age 26 ± 5 yr; height 164 ± 3 cm; weight 63 ± 7 kg) beat-to-beat heart rate (HR) and blood pressure were recorded. Mean arterial pressure (MAP), stroke volume (SV), cardiac index (CI), and total vascular resistance index (TVRI) were calculated. TGS was applied for 3 min at rest and in-between 10-min steady-state cycling exercise at a HR of 110 beats/min, the measurements were obtained during the last minute of each period. At rest, TGS increased MAP (men: Δ18 ± 8 mmHg; women: Δ23 ± 8 mmHg; means ± SD), TVRI (men: Δ1.1 ± 0.6 mmHg·l-1·min·m-2; women: Δ1.2 ± 1.2 mmHg·l-1·min·m-2) and SV (men: Δ19 ± 15 ml; women: Δ16 ± 11 ml) in both groups. CI increased with TGS in women but not in men. However, men presented a bradycardic response to TGS (Δ-11 ± 8 beats/min) that was not significant in women compared with baseline. Cycling exercise increased HR, MAP, SV, and CI and decreased TVRI in men and women. TGS during exercise further increased MAP in men and women and did not change CI in either group. SV and TVRI increased with TGS during exercise only in women. TGS during exercise evoked bradycardia in men (Δ-7 ± 9 beats/min), whereas HR was unchanged in women. Our findings indicate sex differences in TGS-related cardiovascular responses at rest and during exercise.