Serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic Malay patients with first episode of major depressive disorder
Serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic Malay patients with first episode of major depressive disorder
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DOI：
10.1038/s41397-021-00228-6
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发表时间：
2021-03-17
影响因子：
2.8
通讯作者：
Stanslas, Johnson
中科院分区：
文献类型：
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作者：
Badamasi, Ibrahim Mohammed;Lye, Munn Sann;Stanslas, Johnson
5 HTR 1A和5 HTR 2A受体基因（rs6295 C/G和rs6311 G/A）的多态性与SSRI治疗结果的相关性在不同人群中进行了评估，结果不同。本研究旨在确定HTR 1A-rs6295和HTR 2A-rs6311基因型与SSRI治疗结果之间的相关性，这些患者被诊断为首次发作的重度抑郁症（MDD）。这些患者是从马来西亚巴生谷地区的四家三级医院招募的。本研究采用基于蒙哥马利阿斯伯格抑郁量表自评评分（MADRS-S）降低25%（部分早期应答）和50%（临床有效应答）的预定义疗效表型进行治疗疗效评估。使用SSRI治疗长达6周后的患者不良反应量表（PRISE）记录不良反应（AE）的自我报告。使用测序技术获得的多态性基因型与治疗结果表型之间进行了校正的二元logistic回归。招募的142例患者中，女性96例（67.6%），男性46例（32.4%）。HTR 1A和HTR 2A基因多态性与临床疗效和部分早期缓解表型无显著相关性。HTR 2A多态性的GG基因型降低了头晕（CNS）的几率，增加了注意力不集中的几率。GA基因型增加了多汗、腹泻、便秘和视力模糊的几率。HTR 1A-rs6295的CC基因型降低了恶心/呕吐的几率，增加了焦虑的几率。因此，HTR 1A和HTR 2A多态性的一些基因型与马来族MDD患者的SSRI治疗结果相关。
The polymorphisms of the 5HTR1A and 5HTR2A receptor genes (rs6295C/G and rs6311G/A) have been evaluated for association with SSRI treatment outcome in various populations with different results. The present study was carried out to determine the association between genotypes of HTR1A-rs6295 and HTR2A-rs6311 with SSRI treatment outcome among the ethnic Malay patients diagnosed with first-episode major depressive disorder (MDD). The patients were recruited from four tertiary hospitals in the Klang Valley region of Malaysia. Predefined efficacy phenotypes based on 25% (partial early response) and 50% (clinical efficacy response) reduction in Montgomery Asberg Depression Rating Scale-self Rated score (MADRS-S) were adopted for assessment of treatment efficacy in this study. Self-reporting for adverse effects (AE) was documented using the Patient Rated Inventory of Side Effect (PRISE) after treatment with SSRI for up to 6 weeks. Adjusted binary logistic regression between genotypes of the polymorphism obtained using sequencing technique with the treatment outcome phenotypes was performed. The 142 patients recruited were made up of 96 females (67.6%) and 46 males (32.4%). Clinical efficacy and Partial early response phenotypes were not significantly associated with genotypes of HTR1A and HTR2A polymorphism. The GG genotype of HTR2A polymorphism has decreased odds for dizziness (CNS) and increased odds for poor concentration. The GA genotype increases the odd for excessive sweating, diarrhoea, constipation and blurred vision. The CC genotype of HTR1A-rs6295 decreases the odd for nausea/vomiting and increases the odd for anxiety. Thus, some genotypes of HTR1A and HTR2A polymorphism were associated with SSRI treatment outcomes in ethnic Malay MDD patients.