CD34 AND FACTOR-XIIIA IN THE DIFFERENTIAL-DIAGNOSIS OF DERMATOFIBROMA AND DERMATOFIBROSARCOMA PROTUBERANS
CD34 AND FACTOR-XIIIA IN THE DIFFERENTIAL-DIAGNOSIS OF DERMATOFIBROMA AND DERMATOFIBROSARCOMA PROTUBERANS
复制标题
DOI：
10.1097/00000372-199310000-00003
复制
发表时间：
1993-10-01
影响因子：
1.1
通讯作者：
LILLEMOE, T
中科院分区：
文献类型：
--
作者：
ABENOZA, P;LILLEMOE, T
为了评估抗cd34和抗因子xiiia抗体在皮肤纤维瘤（DF）和隆突性皮肤纤维肉瘤（DFSP）鉴别诊断中的应用，我们对40例DF和13例DFSP进行了染色。在90%的DFs中，树突状细胞和梭形细胞对抗因子xiiia有明显的反应。在DFSP中，大多数病例对这种抗血清的反应性细胞很少或没有反应性细胞，反应性仅限于肿瘤的浸润边缘或肿瘤主体内非常低百分比的细胞。检测到明显的重叠，这是染色有用但缺乏绝对特异性的原因。在所有具有50-100%活性细胞的DFSP病例中均发现人祖细胞抗原（CD34），但仅在5例DFs中发现。在DFs中，CD34的反应性是局灶性的，只有小于或等于20%的细胞呈阳性。当与其他组织病理学标准一起使用时，因子- xiiia抗体，特别是CD34可能有助于区分这两种过程。
To assess the use of anti-CD34 and anti-factor-XIIIa antibodies for the differential diagnosis of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP), we stained 40 DFs and 13 DFSPs. A significant population of dendritic and spindle cells was reactive with anti-factor-XIIIa in 90% of DFs. In DFSP, most cases had very few or no reactive cells for this antiserum and reactivity was confined to the infiltrating edges of the neoplasm or to a very low percentage of cells within the bulk of the tumor. A significant overlap was detected, a reason why the stain is useful but lacks absolute specificity for this purpose. Human progenitor cell antigen (CD34) was found in all cases of DFSP that had 50-100% of reactive cells, but in only five DFs. In DFs, the reactivity for CD34 was focal, with only less-than-or-equal-to 20% positive cells. When used together with other histopathological criteria, factor-XIIIa antibody and particularly CD34 may help to differentiate these two processes.