DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer.
DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer.
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DOI：
10.1155/2017/3726595
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Cheng YY
中科院分区：
文献类型：
--
作者：
Leygo C;Williams M;Jin HC;Chan MWY;Chu WK;Grusch M;Cheng YY
鉴于癌症的高发病率和死亡率，早期和准确的诊断是为每个疑似疾病患者分配最佳治疗的重要优先事项。生物标志物在筛查癌症高危患者、尽早诊断可疑肿瘤患者、建立准确的预后以及预测和监测对特定疗法的反应方面至关重要。表观遗传改变是癌症的创新生物标志物，由于其稳定性，频率和体液中的非侵入性可及性。表观遗传修饰也是可逆的，并可能用作治疗靶点。尽管如此，仍然缺乏用于大多数癌症类型的结论性诊断的准确生物标志物;因此，迫切需要继续研究以扩大这一研究领域。在这篇综述中，我们总结了甲基化DNA及其在癌症中的意义，探讨其作为表观遗传生物标志物的潜力，以转化为临床应用。我们建议，以更高的准确性和更有效的检测方法鉴定生物标志物将能够改善患者的临床管理和早期疾病的干预。
In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an important priority for assigning optimal treatment for each individual with suspected illness. Biomarkers are crucial in the screening of patients with a high risk of developing cancer, diagnosing patients with suspicious tumours at the earliest possible stage, establishing an accurate prognosis, and predicting and monitoring the response to specific therapies. Epigenetic alterations are innovative biomarkers for cancer, due to their stability, frequency, and noninvasive accessibility in bodily fluids. Epigenetic modifications are also reversible and potentially useful as therapeutic targets. Despite this, there is still a lack of accurate biomarkers for the conclusive diagnosis of most cancer types; thus, there is a strong need for continued investigation to expand this area of research. In this review, we summarise current knowledge on methylated DNA and its implications in cancer to explore its potential as an epigenetic biomarker to be translated for clinical application. We propose that the identification of biomarkers with higher accuracy and more effective detection methods will enable improved clinical management of patients and the intervention at early-stage disease.
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影响因子：
2.2
作者：
Eggert, Julia A.;Palavanzadeh, Mahsa;Blanton, Amanda
通讯作者：
Blanton, Amanda
影响因子：
9.3
作者：
deVos, Theo;Tetzner, Reimo;Lofton-Day, Catherine
通讯作者：
Lofton-Day, Catherine
影响因子：
120.7
作者：
Bach, Peter B.;Mirkin, Joshua N.;Oliver, Thomas K.;Azzoli, Christopher G.;Berry, Donald A.;Brawley, Otis W.;Byers, Tim;Colditz, Graham A.;Gould, Michael K.;Jett, James R.;Sabichi, Anita L.;Smith-Bindman, Rebecca;Wood, Douglas E.;Qaseem, Amir;Detterbeck, Frank C.
通讯作者：
Detterbeck, Frank C.
DOI：
10.1196/annals.1448.039
发表时间：
2008-01-01
期刊：
CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM V
影响因子：
--
作者：
Bryzgunova, Olga E.;Morozkin, Evgeniy S.;Laktionov, Pavel P.
通讯作者：
Laktionov, Pavel P.
影响因子：
11.5
作者：
Friedrich, MG;Weisenberger, DJ;Liang, GN
通讯作者：
Liang, GN