Manifestations of cancer cachexia induced by colon 26 adenocarcinoma are not fully ascribable to interleukin‐6
Manifestations of cancer cachexia induced by colon 26 adenocarcinoma are not fully ascribable to interleukin‐6
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结肠 26 腺癌引起的癌症恶病质的表现并不完全归因于白细胞介素-6
DOI：
10.1002/ijc.2910620317
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发表时间：
1995
影响因子：
6.4
通讯作者：
M. Miyata
中科院分区：
文献类型：
--
作者：
K. Soda;M. Kawakami;A. Kashii;M. Miyata
为了进一步阐明白细胞介素6（IL-6）在恶病质发病机制中的作用，将重组人IL-6（hIL-6）皮下给药。通过渗透泵以1或10 μg/天的剂量对接种结肠26腺癌的非恶病质诱导亚克隆（克隆5）或该恶性肿瘤的恶病质诱导亚克隆（克隆20）的CDFI小鼠进行9天给药。在肿瘤接种后第19天，具有克隆5肿瘤的非恶病质小鼠的血清IL-6水平比具有结肠26腺癌的克隆20的恶病质小鼠低35%。IL-6给药不仅在克隆5肿瘤小鼠中诱导贫血、血小板增多和内脏器官肥大，而且在无肿瘤负荷的对照小鼠中也诱导贫血、血小板增多和内脏器官肥大。当将大剂量（10 μg/天）的IL-6输注到具有克隆-5肿瘤的小鼠中时，脂解和蛋白水解变得明显。然而，IL-6补充剂不会诱导体重减轻、摄食量下降或淋巴细胞减少，这些在患有克隆-20肿瘤的恶病质小鼠中观察到。总之，IL-6似乎是恶病质发展的容许因子，但是，虽然它可以诱导恶病质的一些典型症状，但它本身不能诱导完全的恶病质综合征。© 1995 Wiley利斯公司
In order to further clarify the role of interleukin 6 (IL‐6) in the pathogenesis of cachexia, recombinant human IL‐6 (hIL‐6) was administered s.c. by osmotic pump for 9 days at a dose of 1 or 10 μg/day into CDFI mice inoculated with a non‐cachexia‐inducing subclone of colon 26 adenocarcinoma (clone 5), or with a cachexia‐inducing subclone (clone 20) of this malignancy. The serum level of IL‐6 in non‐cachectic mice with clone‐5 tumors was 35% lower than in cachectic mice bearing clone 20 of colon 26 adenocarcinoma on the 19th day after tumor inoculation. IL‐6 administration induced anemia, thrombocytosis and visceral organ hypertrophy not only in mice with clone‐5 tumors but also in control mice with no tumor burden. Lipolysis and proteolysis became conspicuous when a large dose (10 μg/day) of IL‐6 was infused into mice with clone‐5 tumors. However, IL‐6 supplementation did not induce loss of body weight, a decline in food intake or lymphocytopenia, which were characteristically observed in cachectic mice with clone‐20 tumors. In conclusion, IL‐6 appears to be a permissive factor for the development of cachexia but, while it can induce some of the symptoms typical of cachexia, it cannot in itself induce the full cachectic syndrome. © 1995 Wiley‐Liss Inc.
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有证据表明肿瘤坏死因子在裸鼠人类肿瘤恶病质、高钙血症和白细胞增多等副肿瘤综合征中发挥致病作用。
DOI：
10.1172/jci115106
发表时间：
1991
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Yoneda,T;Alsina,MA;Chavez,JB;Bonewald,L;Nishimura,R;Mundy,GR
通讯作者：
Mundy,GR
人体血液中“复合”白细胞介素 6 含量高。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
May,LT;Viguet,H;Kenney,JS;Ida,N;Allison,AC;Sehgal,PB
通讯作者：
Sehgal,PB
循环 IL-6 的抗体伴侣。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
May,LT;Neta,R;Moldawer,LL;Kenney,JS;Patel,K;Sehgal,PB
通讯作者：
Sehgal,PB
影响因子：
5.9
作者：
DEWYS, WD;BEGG, C;SKEEL, RT
通讯作者：
SKEEL, RT