What Are Clinically Relevant Levels of Cellular and Biomolecular Analytes?
What Are Clinically Relevant Levels of Cellular and Biomolecular Analytes?
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DOI：
10.1021/acssensors.6b00691
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发表时间：
2017-02-01
期刊：
影响因子：
8.9
通讯作者：
Kelley, Shana O.
中科院分区：
文献类型：
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作者：
Kelley, Shana O.
开发用于生物分子分析物的传感器的最终目标是提供用于分析疾病的生物标志物的临床标本的新工具。因此，了解临床上常规用于特定适应症的样本类型以及这些样本中相关分析物的典型水平非常重要。这篇传感器问题文章总结了有关目标分子和细胞水平的信息，这些分子和细胞对开发传染病和癌症的新诊断方法感兴趣。掌握这些信息有助于更好地定义与开发具有所需灵敏度和特异性水平的强大传感器相关的“大海捞针”挑战。
The ultimate goal of developing sensors for biomolecular analytes is to offer new tools for the analysis of clinical specimens for biomarkers of disease. It is thus important to understand the types of samples that are routinely used in the clinic for specific indications, and what the typical levels of relevant analytes are in these specimens. This Sensor Issues article summarizes information concerning levels of target molecules and cells that are of interest for the development of new diagnostics for infectious disease and cancer. Having this information in hand helps better define the "needle-in-a-haystack" challenge associated with developing robust sensors with the needed levels of sensitivity and specificity.