Non-coding RNAs in gastric cancer
Non-coding RNAs in gastric cancer
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胃癌中的非编码RNA
DOI：
10.1016/j.canlet.2020.06.022
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发表时间：
2020-11-28
期刊：
影响因子：
9.7
通讯作者：
Zhou, Tianhua
中科院分区：
文献类型：
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作者：
Xie, Shanshan;Chang, Yongxia;Zhou, Tianhua
非编码RNA（Non-coding RNA，ncRNA）是一类功能性RNA分子，在许多基本的生物学过程中起着重要的调控作用。ncRNA的失调与包括胃癌在内的人类癌症的进展显著相关。本文综述了lncRNA、miRNAs、circRNA和piRNA的致瘤或抑瘤作用及其调控机制，并探讨了它们作为胃癌生物标志物或治疗靶点的潜力。
Non-coding RNAs (ncRNAs) are functional RNA molecules that play crucial regulatory roles in many fundamental biological processes. The dysregulation of ncRNAs is significantly associated with the progression of human cancers, including gastric cancer. In this review, we have summarized the oncogenic or tumorsuppressive roles and the regulatory mechanisms of lncRNAs, miRNAs, circRNAs and piRNAs, and have discussed their potential as biomarkers or therapeutic targets in gastric cancer.