Helicobacter pylori genetic diversity and risk of human disease
Helicobacter pylori genetic diversity and risk of human disease
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DOI：
10.1172/jci12672
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发表时间：
2001-04-01
影响因子：
15.9
通讯作者：
Berg, DE
中科院分区：
文献类型：
--
作者：
Blaser, MJ;Berg, DE
Barrett食管和食管腺癌(5)。因此，从临床和流行病学研究来看，幽门螺杆菌的致病意义是混合的。只有一小部分幽门螺杆菌携带者患病或免于患病，而对于大多数携带者而言，发病率和死亡率不受其幽门螺杆菌状态的影响。从这个意义上说，幽门螺杆菌可以被认为是一种共生菌，或者更确切地说，与人类（如拟杆菌种）有一种“两栖”关系，其致病意义取决于环境(6)。定殖结果的差异可能取决于定殖幽门螺杆菌菌株之间的差异、环境辅助因素或个体宿主决定的因素。特别是，dna水平的分析表明，幽门螺杆菌是最具遗传多样性的细菌物种之一（3,7,8）。虽然大部分多样性可能是中性的，但有些会影响这些细菌定植、持续存在和/或影响特定宿主疾病的能力。我们的目的是评估幽门螺杆菌DNA序列多样性（多态性）如何在微生物和宿主之间的信号传导的更广泛背景下影响疾病风险。
Barrett’s esophagus and adenocarcinoma of the esophagus (5). Thus, from clinical and epidemiological studies, the pathogenetic significance of H. pylori is mixed. Both illness and protection from illness occur in only a small fraction of those carrying H. pylori, whereas for most carriers, morbidity and mortality are unaffected by their H. pylori status. In that sense, H. pylori can be considered a type of commensal, or more properly, has an “amphibiotic” relationship with humans (as with Bacteroides species), whose pathogenic significance is determined by context (6). Differences in the consequences of colonization could depend on variation among colonizing H. pylori strains, on environmental cofactors, or on factors determined by the individual host. In particular, DNA-level analyses have indicated that H. pylori is one of the most genetically diverse of bacterial species (3, 7, 8). Although much of the diversity may be neutral, some will affect the ability of these bacteria to colonize, persist, and/or affect disease in particular hosts. We aim to assess how H. pylori DNA sequence diversity (polymorphism) may affect disease risk in the broader context of signaling between microbes and hosts.