A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men
A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men
复制标题
DOI：
10.1016/s0165-1781(01)00285-2
复制
发表时间：
2001-09-20
影响因子：
11.3
通讯作者：
True, WR
中科院分区：
文献类型：
--
作者：
Chantarujikapong, SI;Scherrer, JF;True, WR
广泛性焦虑障碍（GAD）、惊恐障碍（PD）和创伤后应激障碍（PTSD）经常同时发生。我们调查了遗传和环境因素是否以及在多大程度上重叠了广泛性焦虑症、PD和PTSD的症状。研究对象为3327名越南时代双胞胎登记处的同卵和异卵双胞胎成员，他们参加了1992年诊断访谈计划第3版修订版（DIS3R）的电话管理。采用遗传模型拟合来估计遗传和环境因素对GAD症状、PD症状和PTSD终生共存的影响程度。GAD症状的责任是由于PD症状和PTSD共同的37.9%的加性遗传贡献。PD症状的责任与GAD症状和PTSD共同的20.7%的加性遗传贡献和PD症状特异性的20.1%的加性遗传影响有关。GAD和PD症状常见的加性遗传影响占PTSD遗传变异的21.3%。PTSD特有的加性遗传影响占PTSD遗传变异的13.6%。所有三种疾病的剩余差异是由于独特的环境因素，包括常见的和特定于每种表型。这些结果表明，这些疾病各有不同的病因组成部分，也有显著的遗传和独特的环境共同贡献。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
Generalized anxiety disorder (GAD), panic disorder (PD) and post-traumatic stress disorder (PTSD) often co-occur. We investigated whether and to what degree genetic and environmental contributions overlap among symptoms of GAD, symptoms of PD and PTSD. Subjects were 3327 monozygotic and dizygotic male-male twin pair members of the Vietnam Era Twin Registry who participated in a 1992 telephone administration of the Diagnostic Interview Schedule Version 3 Revised (DIS3R). Genetic model fitting was performed to estimate the magnitude of genetic and environmental contributions to the lifetime co-occurrence of GAD symptoms, PD symptoms and PTSD. The liability for GAD symptoms was due to a 37.9% additive genetic contribution common to PD symptoms and PTSD. Liability for PD symptoms was clue to a 20.7% additive genetic contribution common to GAD symptoms and PTSD, and a 20.1% additive genetic influence specific to PD symptoms. Additive genetic influences common to symptoms of GAD and PD accounted for 21.3% of the genetic variance in PTSD. Additive genetic influences specific to PTSD accounted for 13.6% of the genetic variance in PTSD. Remaining variance for all three disorders was due to unique environmental factors both common and specific to each phenotype. These results suggest that these disorders each have etiologically distinct components and also have significant genetic and unique environmental contributions in common. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.